In recent years, the concept of Industry 4.0 has attracted increasing attention around the world. This new approach involves the digital development and transformation of products through the synchronization of processes in real-time. In order to achieve the expected goals and be successful in the application of Industry 4.0 technologies, some important factors need to be identified. For this purpose, critical success factors, consisting of 9 main criteria and thirty sub-criteria, were identified based on a comprehensive literature review and the evaluation of the expert group. In addition to the criteria in the literature, the criteria qualified workforce structure, and project management were included in the study. Technologies that affect the critical success factors of Industry 4.0 were examined using hybrid multi-criteria analysis. In determining the weighting of the criteria, the fuzzy-based best-worst method (F-BWM) was preferred because it can better represent human thinking. In determining the best alternative technology, the combined compromise solution (CoCoSo) method was used, which can flexibly deal with incomplete and uncertain information without too much a priori information. The results showed that vertical integration is the most suitable technology that influences the critical success factors of Industry 4.0.