Cardiac involvement in a patient with B-cell lymphoblastic lymphoma/acute lymphoblastic leukemia and a history of allogeneic hematopoietic stem cell transplantation and CAR T-cell therapy: A case report
被引:1
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作者:
Cao, Yigeng
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Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
Chinese Acad Med Sci & Peking Union Med Coll, Blood Dis Hosp, Tianjin, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
Cao, Yigeng
[1
,2
]
Liu, Yadan
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机构:
Ningbo First Hosp, Ningbo Clin Res Ctr Hematol Malignancies, Hematol Dept, Ningbo, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
Liu, Yadan
[3
]
Zhang, Rongli
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机构:
Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
Chinese Acad Med Sci & Peking Union Med Coll, Blood Dis Hosp, Tianjin, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
Zhang, Rongli
[1
,2
]
Zhai, Weihua
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机构:
Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
Chinese Acad Med Sci & Peking Union Med Coll, Blood Dis Hosp, Tianjin, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
Zhai, Weihua
[1
,2
]
Ma, Qiaoling
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机构:
Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
Chinese Acad Med Sci & Peking Union Med Coll, Blood Dis Hosp, Tianjin, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
Ma, Qiaoling
[1
,2
]
Wei, Jialin
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Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
Chinese Acad Med Sci & Peking Union Med Coll, Blood Dis Hosp, Tianjin, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
Wei, Jialin
[1
,2
]
Yang, Donglin
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机构:
Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
Chinese Acad Med Sci & Peking Union Med Coll, Blood Dis Hosp, Tianjin, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
Yang, Donglin
[1
,2
]
Pang, Aiming
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机构:
Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
Chinese Acad Med Sci & Peking Union Med Coll, Blood Dis Hosp, Tianjin, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
Pang, Aiming
[1
,2
]
He, Yi
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机构:
Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
Chinese Acad Med Sci & Peking Union Med Coll, Blood Dis Hosp, Tianjin, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
He, Yi
[1
,2
]
Chen, Xin
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机构:
Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
Chinese Acad Med Sci & Peking Union Med Coll, Blood Dis Hosp, Tianjin, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
Chen, Xin
[1
,2
]
Jiang, Erlie
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Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
Chinese Acad Med Sci & Peking Union Med Coll, Blood Dis Hosp, Tianjin, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
Jiang, Erlie
[1
,2
]
Feng, Sizhou
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Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
Chinese Acad Med Sci & Peking Union Med Coll, Blood Dis Hosp, Tianjin, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
Feng, Sizhou
[1
,2
]
Han, Mingzhe
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机构:
Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
Chinese Acad Med Sci & Peking Union Med Coll, Blood Dis Hosp, Tianjin, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
Han, Mingzhe
[1
,2
]
机构:
[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
[2] Chinese Acad Med Sci & Peking Union Med Coll, Blood Dis Hosp, Tianjin, Peoples R China
[3] Ningbo First Hosp, Ningbo Clin Res Ctr Hematol Malignancies, Hematol Dept, Ningbo, Peoples R China
B cell acute lymphoblastic leukemia;
B cell lymphoblastic lymphoma;
allogeneic hematopoietic stem cell transplantation;
chimeric antigen receptor T cells;
cardiac involvement;
MANAGEMENT;
DIAGNOSIS;
NEOPLASMS;
D O I:
10.3389/fimmu.2022.1052336
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Cardiac involvement in hematological malignancies is uncommon, with only a few cases reported to date, and it often leads to a poor prognosis. Here, we report a case of a 42-year-old woman with a history of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and anti-CD19 chimeric antigen receptor (CAR) T-cell therapy for B-cell lymphoblastic lymphoma/acute lymphoblastic leukemia in whom cardiac mass and myocardial infiltration were detected. Prior to this presentation, massive pericardial effusion had occurred 6 months after CAR T-cell therapy, which was improved via ultrasound-guided pericardiocentesis. We observed elevated cytokine levels and increased copy number of CAR DNA in both pericardial effusion and serum. Upon detecting cardiac mass and myocardial infiltration, the patient was administered tocilizumab (a humanized monoclonal antibody against IL-6 receptor), which controlled the serum cytokine levels, and reduced intensity chemotherapy, including vindesine, cyclophosphamide, and prednisolone. However, the patient finally died of multiple organ failure. To the best of our knowledge, this is the first report on the development of a cardiac mass and occurrence of myocardial infiltration after allo-HSCT and CAR T-cell therapy. This report may provide supporting data for the early diagnosis and immediate treatment of patients with cardiac involvement.
机构:
Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol & Blood Dis Hosp, Haihe Lab Cell Ecosyst, State Key Lab Expt Hematol,Natl Clin Res Ctr Bloo, Tianjin, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Hematol & Blood Dis Hosp, Haihe Lab Cell Ecosyst, State Key Lab Expt Hematol,Natl Clin Res Ctr Bloo, Tianjin, Peoples R China
Zhao, Liping
Zhou, Qi
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机构:
Gobroad Res Ctr, Beijing, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Hematol & Blood Dis Hosp, Haihe Lab Cell Ecosyst, State Key Lab Expt Hematol,Natl Clin Res Ctr Bloo, Tianjin, Peoples R China
Zhou, Qi
Chen, Chen
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Gobroad Res Ctr, Beijing, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Hematol & Blood Dis Hosp, Haihe Lab Cell Ecosyst, State Key Lab Expt Hematol,Natl Clin Res Ctr Bloo, Tianjin, Peoples R China
Chen, Chen
Ling, Zhuojun
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机构:
Beijing GoBroad Boren Hosp, Beijing, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Hematol & Blood Dis Hosp, Haihe Lab Cell Ecosyst, State Key Lab Expt Hematol,Natl Clin Res Ctr Bloo, Tianjin, Peoples R China
Ling, Zhuojun
Wang, Kai
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Beijing GoBroad Boren Hosp, Beijing, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Hematol & Blood Dis Hosp, Haihe Lab Cell Ecosyst, State Key Lab Expt Hematol,Natl Clin Res Ctr Bloo, Tianjin, Peoples R China
Wang, Kai
Wu, Fan
论文数: 0引用数: 0
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机构:
Beijing GoBroad Boren Hosp, Beijing, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Hematol & Blood Dis Hosp, Haihe Lab Cell Ecosyst, State Key Lab Expt Hematol,Natl Clin Res Ctr Bloo, Tianjin, Peoples R China
Wu, Fan
Xu, Jinlong
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机构:
Beijing GoBroad Boren Hosp, Beijing, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Hematol & Blood Dis Hosp, Haihe Lab Cell Ecosyst, State Key Lab Expt Hematol,Natl Clin Res Ctr Bloo, Tianjin, Peoples R China
Xu, Jinlong
Duan, Jiajia
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Beijing GoBroad Boren Hosp, Beijing, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Hematol & Blood Dis Hosp, Haihe Lab Cell Ecosyst, State Key Lab Expt Hematol,Natl Clin Res Ctr Bloo, Tianjin, Peoples R China
Duan, Jiajia
Wang, Zelin
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Beijing GoBroad Boren Hosp, Beijing, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Hematol & Blood Dis Hosp, Haihe Lab Cell Ecosyst, State Key Lab Expt Hematol,Natl Clin Res Ctr Bloo, Tianjin, Peoples R China
Wang, Zelin
Wang, Quangang
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机构:
Beijing GoBroad Boren Hosp, Beijing, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Hematol & Blood Dis Hosp, Haihe Lab Cell Ecosyst, State Key Lab Expt Hematol,Natl Clin Res Ctr Bloo, Tianjin, Peoples R China
Wang, Quangang
Pan, Jing
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Beijing GoBroad Boren Hosp, Beijing, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Hematol & Blood Dis Hosp, Haihe Lab Cell Ecosyst, State Key Lab Expt Hematol,Natl Clin Res Ctr Bloo, Tianjin, Peoples R China
机构:
Smt Radhikabai Meghe Mem Coll Nursing Sawangi Meg, Wardha, Maharashtra, IndiaDatta Meghe Inst Med Sci Deemed Univ Maharashtra, Smt Radhikabai Meghe Mem Coll Nursing Sawangi Meg, Dept Child Hlth Nursing, Wardha, India
Watmode, Ankita
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Kurian, Bibin
Meshram, Khushbu
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Datta Meghe Inst Med Sci Deemed Univ Maharashtra, Smt Radhikabai Meghe Mem Coll Nursing Sawangi Meg, Dept Child Hlth Nursing, Wardha, IndiaDatta Meghe Inst Med Sci Deemed Univ Maharashtra, Smt Radhikabai Meghe Mem Coll Nursing Sawangi Meg, Dept Child Hlth Nursing, Wardha, India
Meshram, Khushbu
Kolhekar, Sonali
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Datta Meghe Inst Med Sci Deemed Univ Maharashtra, Smt Radhikabai Meghe Mem Coll Nursing Sawangi Meg, Dept Child Hlth Nursing, Wardha, IndiaDatta Meghe Inst Med Sci Deemed Univ Maharashtra, Smt Radhikabai Meghe Mem Coll Nursing Sawangi Meg, Dept Child Hlth Nursing, Wardha, India
Kolhekar, Sonali
Sawarkar, Achita
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Datta Meghe Inst Med Sci Deemed Univ Maharashtra, Smt Radhikabai Meghe Mem Coll Nursing Sawangi Meg, Dept Community Hlth Nursing, Wardha, IndiaDatta Meghe Inst Med Sci Deemed Univ Maharashtra, Smt Radhikabai Meghe Mem Coll Nursing Sawangi Meg, Dept Child Hlth Nursing, Wardha, India
Sawarkar, Achita
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Shambharkar, Madhuri
Tembhare, Vaishali
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Datta Meghe Inst Med Sci DU Sawangi M, Jawaharlal Nehru Med Coll, Wardha, IndiaDatta Meghe Inst Med Sci Deemed Univ Maharashtra, Smt Radhikabai Meghe Mem Coll Nursing Sawangi Meg, Dept Child Hlth Nursing, Wardha, India
机构:
Univ Missouri Kansas City, Childrens Mercy Hosp, Div Hematol Oncol Cellular Therapy & Stem Cell Tr, Kansas City, MO 64110 USAUniv Missouri Kansas City, Childrens Mercy Hosp, Div Hematol Oncol Cellular Therapy & Stem Cell Tr, Kansas City, MO 64110 USA
Myers, G. Doug
Verneris, Michael R.
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机构:
Univ Colorado, Sect Blood & Marrow Transplantat & Cellular Thera, Canc & Blood Disorders, Denver, CO USAUniv Missouri Kansas City, Childrens Mercy Hosp, Div Hematol Oncol Cellular Therapy & Stem Cell Tr, Kansas City, MO 64110 USA
Verneris, Michael R.
Goy, Andre
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h-index: 0
机构:
Hackensack Univ, John Theurer Canc Ctr, Div Lymphoma, Med Ctr, Hackensack, NJ USAUniv Missouri Kansas City, Childrens Mercy Hosp, Div Hematol Oncol Cellular Therapy & Stem Cell Tr, Kansas City, MO 64110 USA
Goy, Andre
Maziarz, Richard T.
论文数: 0引用数: 0
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机构:
Oregon Hlth & Sci Univ, Knight Canc Inst, BMT & Cell Therapy Program, Div Hematol Med Oncol, Portland, OR USAUniv Missouri Kansas City, Childrens Mercy Hosp, Div Hematol Oncol Cellular Therapy & Stem Cell Tr, Kansas City, MO 64110 USA