Following the Birth, Life, and Death of mRNAs in Single Cells

被引：0
|
作者：
Eichenberger, Bastian T. [1 ,2 ]
Griesbach, Esther [1 ]
Mitchell, Jessica [1 ]
Chao, Jeffrey A. [1 ]
机构：
[1] Friedrich Miescher Inst Biomed Res, Basel, Switzerland
[2] Univ Basel, Basel, Switzerland
来源：
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 2023年 / 39卷
基金：
瑞士国家科学基金会;
关键词：
fluorescence microscopy; transcription; splicing; RNA localization; translation; mRNA decay; GENE-EXPRESSION; NUCLEAR SPECKLES; LIVE-CELL; TRANSLATION DYNAMICS; REVEALS; TRANSPORT; TRANSCRIPTION; LOCALIZATION; VISUALIZATION; TISSUE;
D O I：
10.1146/annurev-cellbio-022723-024045
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Recent advances in single-molecule imaging of mRNAs in fixed and living cells have enabled the lives of mRNAs to be studied with unprecedented spatial and temporal detail. These approaches have moved beyond simply being able to observe specific events and have begun to allow an understanding of how regulation is coupled between steps in the mRNA life cycle. Additionally, these methodologies are now being applied in multicellular systems and animals to provide more nuanced insights into the physiological regulation of RNA metabolism.
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页码：253 / 275
页数：23
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