Developmental Trends in Postnatal Thyroid Hormones and Thyroid Dysfunction in Preterm Infants Born at less than 34 weeks Gestation

被引：2
|
作者：
Chen, Shaohong [1 ,2 ]
Lu, Xiaoyan [1 ]
Yang, Bicheng [2 ]
Wu, Jieru [2 ]
Huang, Hui [3 ]
Zou, Yang [2 ]
Tang, Wenyan [2 ]
Xu, Ping [2 ]
Yang, Yu [1 ,3 ,4 ,5 ]
机构：
[1] Nanchang Univ, Med Coll, Nanchang, Jiangxi, Peoples R China
[2] Jiangxi Prov Maternal & Child Hlth Hosp, Nanchang, Jiangxi, Peoples R China
[3] Jiangxi Prov Childrens Hosp, Nanchang, Jiangxi, Peoples R China
[4] Nanchang Univ, Med Coll, Nanchang 330006, Jiangxi, Peoples R China
[5] Jiangxi Prov Childrens Hosp, Nanchang 330006, Jiangxi, Peoples R China
来源：
FETAL AND PEDIATRIC PATHOLOGY | 2023年 / 42卷 / 04期
关键词：
Preterm; transient hypothyroxinaemia of prematurity; congenital hypothyroidism; thyroid function; delayed TSH elevation; BIRTH-WEIGHT INFANTS; TRANSIENT HYPOTHYROXINEMIA; CONGENITAL HYPOTHYROIDISM; REFERENCE INTERVALS; PREMATURITY; ELEVATION; CHILDREN; HEALTHY;
D O I：
10.1080/15513815.2023.2195520
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
ObjectivesTo analyse the trends in thyroid function tests (TFT) in preterm infants, evaluate the frequency of thyroid dysfunction, and identify the factors that influence thyroid function.MethodsThe TFT results and risk factors for thyroid dysfunction in preterm infants with gestational ages (GA) between 25 and 34 weeks were analysed.ResultsIn total, 535 infants were enrolled in this study. Thyroid hormone levels vary with gestational and postnatal age, and the total frequency of thyroid dysfunction is 50.3%. Thirty-one infants (5.8%) had delayed TSH elevation. Transient hypothyroxinaemia of prematurity remained significantly associated with both lower birth weight and GA. Congenital hypothyroidism was significantly associated with lower birth weight, 5 min Apgar score, and dopamine use.ConclusionsThyroid hormone levels in preterm infants are related to gestation and postnatal age, the frequency of thyroid dysfunction in premature infants is high, and is negatively correlated with GA and birth weight.
引用
收藏
页码：619 / 629
页数：11
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