Multicomponent cascade reaction of 3-formylchromones: Highly regioselective synthesis of functionalized pyridin-2(1H)-ones

被引：4

作者：

Yun, Xinghan ^{[1
]}

Chen, Li ^{[1
]}

Lv, Ying ^{[1
]}

Lu, Zihan ^{[1
]}

Huang, Kun ^{[1
]}

Yan, Shengjiao ^{[1
]}

机构：

[1] Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China

来源：

GREEN SYNTHESIS AND CATALYSIS | 2023年 / 4卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Pyridin-2(1 H )-ones; Cascade reaction; Selective synthesis; 3-Formylchromones; DISCOVERY;

D O I：

10.1016/j.gresc.2022.05.002

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel protocol was developed for the construction of highly functionalized pyridin-2(1H)-ones from 3-formyl-chromones, ethyl 2-(pyridin-2-yl)acetate derivatives and amines via a complex multicomponent cascade reaction involving targeted duplicated ring-opening and duplicated cyclization reactions which form skeleton-reorganized target compounds. A series of pyridin-2(1H)-ones were produced by this reaction accompanied by the formation of three bonds (one C-N and two C-C bonds) and the cleavage of one bond in one step. This protocol can be used in combinatorial and parallel syntheses of various pyridin-2(1H)-ones with potent biological activity. The advantages of this approach include simple and practical operation (multicomponent one-pot), high yields (up to 91%), and products with potential biological activity.

引用

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页码：231 / 239

页数：9

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