Evaluation of Proteasome and Immunoproteasome Levels in Plasma and Peritoneal Fluid in Patients with Endometriosis

被引：2

作者：

Wrobel, Monika ^{[1
]}

Zuzanna, Zielinska ^{[2
]}

Oldak, Lukasz ^{[2
,3
]}

Kalicka, Aleksandra ^{[4
]}

Manka, Grzegorz ^{[5
]}

Kiecka, Mariusz ^{[5
]}

Spaczynski, Robert Z. ^{[6
]}

Piekarski, Piotr ^{[7
]}

Banaszewska, Beata ^{[8
]}

Jakimiuk, Artur ^{[9
,10
]}

Issat, Tadeusz ^{[11
]}

Rokita, Wojciech ^{[12
,13
]}

Mlodawski, Jakub ^{[12
,13
]}

Szubert, Maria ^{[14
,15
]}

Sieroszewski, Piotr ^{[14
,16
]}

Raba, Grzegorz ^{[17
,18
]}

Szczupak, Kamil ^{[17
,18
]}

Kluz, Tomasz ^{[19
]}

Kluza, Marek ^{[19
]}

Pierzynski, Piotr ^{[20
]}

Wojtyla, Cezary ^{[20
]}

Lipa, Michal ^{[21
]}

Warzecha, Damian ^{[20
,21
]}

Wielgos, Miroslaw ^{[22
,23
]}

Sawicki, Wlodzimierz ^{[24
]}

Gorodkiewicz, Ewa ^{[3
]}

Laudanski, Piotr ^{[20
,24
,25
]}

机构：

[1] Med Univ Warsaw, Dept Obstet & Gynecol 1, PL-02015 Warsaw, Poland

[2] Univ Bialystok, Fac Chem, Doctoral Sch Exact & Nat Sci, Bioanal Lab, Ciolkowskiego 1K, PL-15245 Bialystok, Poland

[3] Univ Bialystok, Fac Chem, Bioanal Lab, Ciolkowskiego 1K, PL-15245 Bialystok, Poland

[4] Med Univ Warsaw, Fac Med, Zwirki i Wigury 61, PL-02091 Warsaw, Poland

[5] Angelius Provita Hosp, PL-40611 Katowice, Poland

[6] Ctr Gynecol Obstet & Infertil Treatment Pastelova, PL-60198 Poznan, Poland

[7] Poznan Univ Med Sci, Dept Gynecol Obstet & Gynecol Oncol, Div Infertil & Reprod Endocrinol, PL-61701 Poznan, Poland

[8] Poznan Univ Med Sci, Chair & Dept Lab Diagnost, PL-61701 Poznan, Poland

[9] Inst Mother & Child Warsaw, Dept Reprod Hlth, PL-01211 Warsaw, Poland

[10] Minist Interior, Dept Obstet & Gynecol, Cent Clin Hosp, PL-02507 Warsaw, Poland

[11] Inst Mother & Child Warsaw, Dept Obstet & Gynecol, PL-01211 Warsaw, Poland

[12] Jan Kochanowski Univ Kielce, Coll Med, PL-25516 Kielce, Poland

[13] Prov Combined Hosp Kielce, Clin Obstet & Gynecol, PL-25736 Kielce, Poland

[14] Med Univ Lodz, Dept Gynecol & Obstet, PL-90419 Lodz, Poland

[15] Med Univ Lodz, Dept Surg Gynecol & Oncol, PL-90419 Lodz, Poland

[16] Med Univ Lodz, Dept Fetal Med & Gynecol, PL-90419 Lodz, Poland

[17] Clin Obstet & Gynecol Przemysl, PL-37700 Przemysl, Poland

[18] Univ Rzeszow, Dept Obstet & Gynecol, PL-35310 Rzeszow, Poland

[19] Rzeszow Univ, Inst Med Sci, Dept Gynecol Gynecol Oncol & Obstet, Med Coll, PL-35310 Rzeszow, Poland

[20] OVIklin Infertil Ctr, 31 Polczynska St, PL-01377 Warsaw, Poland

[21] City South Hosp Warsaw, PL-02781 Warsaw, Poland

[22] Premium Med Clin, PL-04359 Warsaw, Poland

[23] Lazarski Univ, Med Fac, PL-02662 Warsaw, Poland

[24] Med Univ Warsaw, Dept Obstet Gynecol & Gynecol Oncol, PL-03242 Warsaw, Poland

[25] Calisia Univ, Womens Hlth Res Inst, PL-62800 Kalisz, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 18期

关键词：

endometriosis; proteasome; immunoproteasome; plasma; peritoneal fluid; INHIBITORS; AUTOIMMUNE; MARKER;

D O I：

10.3390/ijms241814363

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endometriosis is a chronic disease in which the endometrium cells are located outside the uterine cavity. The aim of this study was to evaluate circulating 20S proteasome and 20S immunoproteasome levels in plasma and peritoneal fluid in women with and without endometriosis in order to assess their usefulness as biomarkers of disease. Concentrations were measured using surface plasmon resonance imaging biosensors. Patients with suspected endometriosis were included in the study-plasma was collected in 112 cases and peritoneal fluid in 75. Based on the presence of endometriosis lesions detected during laparoscopy, patients were divided into a study group (confirmed endometriosis) and a control group (patients without endometriosis). Proteasome and immunoproteasome levels in both the plasma (p = 0.174; p = 0.696, respectively) and the peritoneal fluid (p = 0.909; p = 0.284, respectively) did not differ between those groups. There was a statistically significant difference in the plasma proteasome levels between patients in the control group and those with mild (Stage I and II) endometriosis (p = 0.047) and in the plasma immunoproteasome levels in patients with ovarian cysts compared to those without (p = 0.017). The results of our study do not support the relevance of proteasome and immunoproteasome determination as biomarkers of the disease but suggest a potentially active role in the pathogenesis of endometriosis.

引用

页数：18

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