Recent Advances, Challenges, and Metabolic Engineering Strategies in L-Cysteine Biosynthesis

被引：1
|
作者：
Li, Wenwei [1 ]
Zhou, Zhen [2 ]
Wang, Dan [1 ]
机构：
[1] Chongqing Univ, Sch Chem & Chem Engn, Dept Chem Engn, Chongqing 401331, Peoples R China
[2] Chongqing Univ, Sch Pharmaceut Sci, Chongqing 401331, Peoples R China
来源：
FERMENTATION-BASEL | 2023年 / 9卷 / 09期
基金：
中国国家自然科学基金;
关键词：
L-cysteine; Escherichia coli; Corynebacterium glutamicum; metabolic engineering; synthetic biology; SERINE O-ACETYLTRANSFERASE; MICROBIAL CELL FACTORIES; ESCHERICHIA-COLI; CORYNEBACTERIUM-GLUTAMICUM; D; L-2-AMINO-DELTA(2)-THIAZOLINE-4-CARBOXYLIC ACID; DL-2-AMINO-DELTA-2-THIAZOLINE-4-CARBOXYLIC ACID; SACCHAROMYCES-CEREVISIAE; FUNCTIONAL-ANALYSIS; IDENTIFICATION; OVERPRODUCTION;
D O I：
10.3390/fermentation9090802
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
L-Cysteine is a widely used unique sulfur-containing amino acid with wide application in the food, pharmaceutical, and agricultural industries. This paper concludes the advantages and disadvantages of chemical hydrolysis, enzymatic biotransformation, and fermentation for the synthesis of L-cysteine. Meanwhile, a detailed introduction is given to the biosynthesis of L-cysteine, metabolic engineering strategies, and the latest progress in reported L-cysteine fermentation bacteria. Finally, insights are provided on the development direction of increasing the production of biosynthetic L-cysteine in the future. This review provides ideas for the future development of more efficient L-cysteine biosynthetic pathways.
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页数：13
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