Oreoch-1: A broad-spectrum virus and host-targeting peptide against animal infections

被引:0
|
作者
Nastri, Bianca M. [1 ]
Chianese, Annalisa [1 ]
Giugliano, Rosa [1 ]
Di Clemente, Laura [1 ]
Capasso, Carla [1 ]
Monti, Alessandra [2 ]
Doti, Nunzianna [2 ]
Iovane, Valentina [3 ]
Montagnaro, Serena [4 ]
Pagnini, Ugo [4 ]
Iovane, Giuseppe [4 ]
Zannella, Carla [1 ]
De Filippis, Anna [1 ]
Galdiero, Massimiliano [1 ,5 ,6 ]
机构
[1] Univ Campania Luigi Vanvitelli, Dept Expt Med, Naples, Italy
[2] Natl Res Council CNR, Inst Biostruct & Bioimaging IBB, Naples, Italy
[3] Univ Naples Federico II, Dept Agr Sci, Naples, Italy
[4] Univ Naples Federico II, Dept Vet Med & Anim Prod, Naples, Italy
[5] Univ Hosp Campania Luigi Vanvitelli, UOC Virol & Microbiol, Naples, Italy
[6] Univ Campania Luigi Vanvitelli, Dept Expt Med, I-80138 Naples, Italy
关键词
AMPs; antiviral; bunyavirus; emerging diseases; fish peptides; herpesvirus; oreochromicin-1; paramyxovirus; zoonotic diseases; ANTIMICROBIAL PEPTIDES; ANTIVIRAL ACTIVITY; AGENTS; AMPS; MICE;
D O I
10.1002/psc.3593
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In recent decades, the global rise of viral emerging infectious diseases has posed a substantial threat to both human and animal health worldwide. The rapid spread and accumulation of mutations into viruses, and the limited availability of antiviral drugs and vaccines, stress the urgent need for alternative therapeutic strategies. Antimicrobial peptides (AMPs) derived from natural sources present a promising avenue due to their specificity and effectiveness against a broad spectrum of pathogens. The present study focuses on investigating the antiviral potential of oreochromicin-1 (oreoch-1), a fish-derived AMP obtained from Nile tilapia, against a wide panel of animal viruses including canine distemper virus (CDV), Schmallenberg virus (SBV), caprine herpesvirus 1 (CpHV-1), and bovine herpesvirus 1 (BoHV-1). Oreoch-1 exhibited a strong antiviral effect, demonstrating an inhibition of infection at concentrations in the micromolar range. The mechanism of action involves the interference with viral entry into host cells and a direct interaction between oreoch-1 and the viral envelope. In addition, we observed that the peptide could also interact with the cell during the CDV infection. These findings not only highlight the efficacy of oreoch-1 in inhibiting viral infection but also emphasize the potential of fish-derived peptides, specifically oreoch-1, as effective antiviral agents against viral infections affecting animals, whose potential to spill into humans is high. This research contributes valuable insights to the ongoing quest for novel antiviral drugs with the potential to mitigate the impact of infectious diseases on a global scale. The antiviral potential of the fish-derived antimicrobial peptide oreochromicin-1 (oreoch-1) was investigated against a wide panel of animal viruses. Oreoch-1 exhibited a strong antiviral effect, with the mechanism of action involving the interference with viral entry into host cells and direct interaction between oreoch-1 and the viral envelope. image
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页数:10
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