Gut microbiota and acute kidney injury: immunological crosstalk link

被引:0
|
作者
Ali, Asmaa [1 ,2 ,3 ]
Wu, Liang [4 ]
Ali, Sameh Samir [5 ,6 ]
机构
[1] Jiangsu Univ, Sch Med, Dept Lab Med, Zhenjiang 212013, Peoples R China
[2] Abbassia Chest Hosp, MOH, Dept Pulm Med, Cairo, Egypt
[3] Minist Hlth, Al Rashed Allergy Ctr, Dept Allergy, Kuwait, Kuwait
[4] Yizheng Hosp, Drum Tower Hosp Grp Nanjing, Yizheng 211900, Peoples R China
[5] Jiangsu Univ, Biofuels Inst, Sch Environm & Safety Engn, Zhenjiang 212013, Peoples R China
[6] Tanta Univ, Fac Sci, Bot Dept, Tanta 31527, Egypt
关键词
Gut microbiota; Innate and adaptive immune response; Acute kidney injury; CHAIN FATTY-ACIDS; INNATE LYMPHOID-CELLS; REGULATORY T-CELLS; INTESTINAL MICROBIOTA; BACTEROIDES-THETAIOTAOMICRON; PROTECT MICE; HOST; BACTERIA; IMMUNITY; HEALTH;
D O I
10.1007/s11255-023-03760-5
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The gut microbiota, often called the "forgotten organ," plays a crucial role in bidirectional communication with the host for optimal physiological function. This communication helps regulate the host's immunity and metabolism positively and negatively. Many factors influence microbiota homeostasis and subsequently lead to an immune system imbalance. The correlation between an unbalanced immune system and acute diseases such as acute kidney injury is not fully understood, and the role of gut microbiota in disease pathogenesis is still yet uncovered. This review summarizes our understanding of gut microbiota, focusing on the interactions between the host's immune system and the microbiome and their impact on acute kidney injury.
引用
收藏
页码:1345 / 1358
页数:14
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