The Role of Poly(ADP-ribose) Polymerase 1 in Nuclear and Mitochondrial Base Excision Repair

被引：4
|
作者：
Herrmann, Geoffrey K. [1 ,2 ]
Yin, Y. Whitney [1 ,2 ]
机构：
[1] Univ Texas Med Branch, Dept Biochem & Mol Biol, Galveston, TX 77555 USA
[2] Univ Texas Med Branch, Sealy Ctr Struct Biol, Galveston, TX 77555 USA
来源：
BIOMOLECULES | 2023年 / 13卷 / 08期
基金：
美国国家卫生研究院;
关键词：
PARP-1; nuclear and mitochondrial localization; DNA repair; DNA-LIGASE-III; SINGLE-STRAND BREAKS; POLY-ADP-RIBOSE; STRUCTURAL BASIS; BETA; XRCC1; MECHANISM; DAMAGE; RIBOSYLATION; PARP-1;
D O I：
10.3390/biom13081195
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Poly(ADP-ribose) (PAR) Polymerase 1 (PARP-1), also known as ADP-ribosyl transferase with diphtheria toxin homology 1 (ARTD-1), is a critical player in DNA damage repair, during which it catalyzes the ADP ribosylation of self and target enzymes. While the nuclear localization of PARP-1 has been well established, recent studies also suggest its mitochondrial localization. In this review, we summarize the differences between mitochondrial and nuclear Base Excision Repair (BER) pathways, the involvement of PARP-1 in mitochondrial and nuclear BER, and its functional interplay with other BER enzymes.
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页数：19
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