The Role of Poly(ADP-ribose) Polymerase 1 in Nuclear and Mitochondrial Base Excision Repair

被引：4
|
作者：
Herrmann, Geoffrey K. [1 ,2 ]
Yin, Y. Whitney [1 ,2 ]
机构：
[1] Univ Texas Med Branch, Dept Biochem & Mol Biol, Galveston, TX 77555 USA
[2] Univ Texas Med Branch, Sealy Ctr Struct Biol, Galveston, TX 77555 USA
来源：
BIOMOLECULES | 2023年 / 13卷 / 08期
基金：
美国国家卫生研究院;
关键词：
PARP-1; nuclear and mitochondrial localization; DNA repair; DNA-LIGASE-III; SINGLE-STRAND BREAKS; POLY-ADP-RIBOSE; STRUCTURAL BASIS; BETA; XRCC1; MECHANISM; DAMAGE; RIBOSYLATION; PARP-1;
D O I：
10.3390/biom13081195
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Poly(ADP-ribose) (PAR) Polymerase 1 (PARP-1), also known as ADP-ribosyl transferase with diphtheria toxin homology 1 (ARTD-1), is a critical player in DNA damage repair, during which it catalyzes the ADP ribosylation of self and target enzymes. While the nuclear localization of PARP-1 has been well established, recent studies also suggest its mitochondrial localization. In this review, we summarize the differences between mitochondrial and nuclear Base Excision Repair (BER) pathways, the involvement of PARP-1 in mitochondrial and nuclear BER, and its functional interplay with other BER enzymes.
引用
收藏
页数：19
相关论文
共 50 条
  • [1] Involvement of poly(ADP-ribose) polymerase in base excision repair
    Dantzer, F
    Schreiber, V
    Niedergang, C
    Trucco, C
    Flatter, E
    De la Rubia, G
    Oliver, J
    Rolli, V
    Ménissier-de Murcia, J
    de Murcia, G
    [J]. BIOCHIMIE, 1999, 81 (1-2) : 69 - 75
  • [2] Base excision repair is efficient in cells lacking poly(ADP-ribose) polymerase 1
    Vodenicharov, MD
    Sallmann, FR
    Satoh, MS
    Poirier, GG
    [J]. NUCLEIC ACIDS RESEARCH, 2000, 28 (20) : 3887 - 3896
  • [3] Poly(ADP-ribose) polymerase 1 regulates activity of DNA polymerase β in long patch base excision repair
    Sukhanova, Maria
    Khodyreva, Svetlana
    Lavrik, Olga
    [J]. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2010, 685 (1-2) : 80 - 89
  • [4] Base excision repair is impaired in mammalian cells lacking poly(ADP-ribose) polymerase-1
    Dantzer, F
    de la Rubia, G
    Murcia, JMD
    Hostomsky, Z
    de Murcia, G
    Schreiber, V
    [J]. BIOCHEMISTRY, 2000, 39 (25) : 7559 - 7569
  • [5] Influence of the Poly(ADP-Ribose) Polymerase 1 Level on the Status of Base Excision Repair in Human Cells
    Ilina, E. S.
    Kochetkova, A. S.
    Belousova, E. A.
    Kutuzov, M. M.
    Lavrik, O. I.
    Khodyreva, S. N.
    [J]. MOLECULAR BIOLOGY, 2023, 57 (02) : 272 - 283
  • [6] Influence of the Poly(ADP-Ribose) Polymerase 1 Level on the Status of Base Excision Repair in Human Cells
    E. S. Ilina
    A. S. Kochetkova
    E. A. Belousova
    M. M. Kutuzov
    O. I. Lavrik
    S. N. Khodyreva
    [J]. Molecular Biology, 2023, 57 : 272 - 283
  • [7] AP endonuclease and poly(ADP-ribose) polymerase-1 interact with the same base excision repair intermediate
    Cistulli, C
    Lavrik, OI
    Prasad, R
    Hou, E
    Wilson, SH
    [J]. DNA REPAIR, 2004, 3 (06) : 581 - 591
  • [8] Poly(ADP-ribose) Polymerase-1 Is a Nuclear Epigenetic Regulator of Mitochondrial DNA Repair and Transcription
    Lapucci, Andrea
    Pittelli, Maria
    Rapizzi, Elena
    Felici, Roberta
    Moroni, Flavio
    Chiarugi, Alberto
    [J]. MOLECULAR PHARMACOLOGY, 2011, 79 (06) : 932 - 940
  • [9] Poly(ADP-ribose) polymerase in base excision repair: always engaged, but not essential for DNA damage processing
    Allinson, SL
    Dianova, II
    Dianov, GL
    [J]. ACTA BIOCHIMICA POLONICA, 2003, 50 (01) : 169 - 179
  • [10] POLY(ADP-RIBOSE) POLYMERASE AND NUCLEAR DNA POLYMERASE
    HAINES, ME
    MATHIAS, AP
    JOHNSTON, IR
    [J]. HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1972, 353 (06): : 849 - &
12345