Material and Design Toolkit for Drug Delivery: State of the Art, Trends, and Challenges

被引:5
|
作者
Rad, Monireh Esmaeili [1 ]
Soylukan, Caner [2 ]
Kulabhusan, Prabir Kumar [3 ]
Gunaydin, Beyza Nur [1 ,2 ]
Yuce, Meral [2 ]
机构
[1] Sabanci Univ, Fac Engn & Nat Sci, TR-34956 Istanbul, Turkiye
[2] Sabanci Univ, SUNUM Nanotechnol Res & Applicat Ctr, TR-34956 Istanbul, Turkiye
[3] Int Iberian Nanotechnol Lab, P-4715330 Braga, Portugal
关键词
drug delivery systems; nanoparticles; releasemechanisms; targeted delivery; surface modification; GRAPHENE QUANTUM DOTS; SOLID LIPID NANOPARTICLES; MESOPOROUS SILICA NANOPARTICLES; BETA-CYCLODEXTRIN NANOPARTICLES; LOADED CHITOSAN NANOPARTICLES; CARBON NANOTUBES; IN-VITRO; TARGETED DELIVERY; CANCER-THERAPY; ALBUMIN NANOPARTICLES;
D O I
10.1021/acsami.3c10065
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
The nanomaterial and related toolkit have promising applications for improving human health and well-being. Nanobased drug delivery systems use nanoscale materials as carriers to deliver therapeutic agents in a targeted and controlled manner, and they have shown potential to address issues associated with conventional drug delivery systems. They offer benefits for treating various illnesses by encapsulating or conjugating biological agents, chemotherapeutic drugs, and immunotherapeutic agents. The potential applications of this technology are vast; however, significant challenges exist to overcome such as safety issues, toxicity, efficacy, and insufficient capacity. This article discusses the latest developments in drug delivery systems, including drug release mechanisms, material toolkits, related design molecules, and parameters. The concluding section examines the limitations and provides insights into future possibilities.
引用
收藏
页码:55201 / 55231
页数:31
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