Post-Stroke Environmental Enrichment Improves Neurogenesis and Cognitive Function and Reduces the Generation of Aberrant Neurons in the Mouse Hippocampus

被引：10

作者：

Woitke, Florus ^{[1
]}

Blank, Antonia ^{[1
,2
]}

Fleischer, Anna-Lena ^{[1
,2
]}

Zhang, Shanshan ^{[1
]}

Lehmann, Gina-Marie ^{[1
]}

Broesske, Julius ^{[1
]}

Haase, Madlen ^{[1
]}

Redecker, Christoph ^{[1
,3
]}

Schmeer, Christian W. ^{[1
]}

Keiner, Silke ^{[1
]}

机构：

[1] Jena Univ Hosp, Dept Neurol, Klinikum 1, D-07747 Jena, Germany

[2] Jena Univ Hosp, Else Kroner Grad Sch Med Students, D-07747 Jena, Germany

[3] Lippe Gen Hosp, Dept Neurol, Rintelner Str 85, D-32657 Lemgo, Germany

来源：

CELLS | 2023年 / 12卷 / 04期

关键词：

MCAO; aberrant neurogenesis; enriched environment; DENTATE GRANULE CELLS; CORTICAL INFARCTS; PROLIFERATIVE RESPONSE; ADULT NEUROGENESIS; STATUS EPILEPTICUS; ISCHEMIC-STROKE; SEIZURES; EXERCISE; GYRUS; THROMBOLYSIS;

D O I：

10.3390/cells12040652

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ischemic lesions stimulate adult neurogenesis in the dentate gyrus, however, this is not associated with better cognitive function. Furthermore, increased neurogenesis is associated with the formation of aberrant neurons. In a previous study, we showed that a running task after a stroke not only increases neurogenesis but also the number of aberrant neurons without improving general performance. Here, we determined whether stimulation in an enriched environment after a lesion could increase neurogenesis and cognitive function without enhancing the number of aberrant neurons. After an ischemic stroke induced by MCAO, animals were transferred to an enriched environment containing a running wheel, tunnels and nest materials. A GFP-retroviral vector was delivered on day 3 post-stroke and a modified water maze test was performed 6 weeks after the lesion. We found that the enriched environment significantly increased the number of new neurons compared with the unstimulated stroke group but not the number of aberrant cells after a lesion. Increased neurogenesis after environmental enrichment was associated with improved cognitive function. Our study showed that early placement in an enriched environment after a stroke lesion markedly increased neurogenesis and flexible learning but not the formation of aberrant neurons, indicating that rehabilitative training, as a combination of running wheel training and enriched environment housing, improved functional and structural outcomes after a stroke.

引用

页数：24