CXCL16 Promotes Ly6Chigh Monocyte Infiltration and Impairs Heart Function after Acute Myocardial Infarction

被引：6

作者：

Zhang, Jing ^{[1
,2
,3
]}

Hao, Wenjing ^{[4
]}

Zhang, Junmeng ^{[5
]}

Li, Taotao ^{[1
,2
]}

Ma, Youcai ^{[1
,2
]}

Wang, Yueli ^{[1
,2
]}

Li, Xiaoyan ^{[1
,2
,3
]}

Cui, Wei ^{[1
,2
,3
]}

Du, Jie ^{[1
,2
,3
]}

机构：

[1] Beijing Anzhen Hosp, Capital Med Univ, Beijing, Peoples R China

[2] Minist Educ, Key Lab Remodeling Related Cardiovasc Dis, Beijing, Peoples R China

[3] Beijing Inst Heart Lung & Blood Vessel Dis, Beijing, Peoples R China

[4] ChiFeng Univ, Affiliated Hosp, Chifeng, Peoples R China

[5] Tsinghua Univ, Hosp 1, Beijing, Peoples R China

来源：

JOURNAL OF IMMUNOLOGY | 2023年 / 210卷 / 06期

基金：

中国国家自然科学基金;

关键词：

NITRIC-OXIDE; ISCHEMIA/REPERFUSION INJURY; INFLAMMATORY RESPONSES; SCAVENGER RECEPTOR; REPERFUSION INJURY; SOLUBLE CXCL16; RECRUITMENT; REPAIR; CELLS; ATHEROSCLEROSIS;

D O I：

10.4049/jimmunol.2200249

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

High CXCL16 levels during acute cardiovascular events increase long-term mortality. However, the mechanistic role of CXCL16 in myocardial infarction (MI) is unknown. Here we investigated the role of CXCL16 in mice with MI injury. CXCL16 deficiency increased the survival of mice after MI injury, and inactivation of CXCL16 resulted in improved cardiac function and decreased infarct size. Hearts from CXCL16 inactive mice exhibited decreased infiltration of Ly6Chigh monocytes. In addition, CXCL16 promoted the macrophage expression of CCL4 and CCL5. Both CCL4 and CCL5 stimulated Ly6Chigh monocyte migration, and CXCL16 inactive mice had a reduced expression of CCL4 and CCL5 in the heart after MI. Mechanistically, CXCL16 promoted CCL4 and CCL5 expression by activating the NF -KB and p38 MAPK signaling pathways. Anti-CXCL16 neutralizing Ab administration inhibited Ly6Chigh monocyte infiltration and improved cardiac function after MI. Additionally, anti-CCL4 and anti-CCL5 neutralizing Ab administration inhibited Ly6Chigh monocyte infiltration and improved cardiac function after MI. Thus, CXCL16 aggravated cardiac injury in MI mice by facilitating Ly6Chigh monocyte infiltration. The Journal of Immunology, 2023,210: 820-831.

引用

页码：820 / 831

页数：13

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