Novel therapeutic approaches for pediatric diencephalic tumors: improving functional outcomes

被引：0

作者：

Cockle, Julia V. ^{[1
,2
]}

Corley, Elizabeth A. ^{[3
]}

Zebian, Bassel ^{[4
]}

Hettige, Samantha ^{[5
]}

Vaidya, Sucheta J. ^{[1
]}

Angelini, Paola ^{[1
,2
]}

Stone, Joanna ^{[1
]}

Leitch, R. Jane ^{[6
]}

Albanese, Assunta ^{[1
,7
]}

Mandeville, Henry C. ^{[1
,2
,8
]}

Carceller, Fernando ^{[1
,2
,3
]}

Marshall, Lynley V. ^{[1
,2
,3
]}

机构：

[1] Royal Marsden Natl Hlth Serv NHS Fdn Trust, Children & Young Peoples Unit, Dept Neurooncol, London, England

[2] Inst Canc Res, Div Clin Studies, London, England

[3] Royal Marsden Natl Hlth Serv NHS Fdn Trust, Children & Young Peoples Unit, Pediat & Adolescent Oncol Drug Dev Team, London, England

[4] Kings Coll Hosp Natl Hlth Serv NHS Trust, Dept Neurosurg, London, England

[5] St Georges Univ Hosp Natl Hlth Serv NHS Fdn Trust, Atkinson Morley Neurosurg Ctr, London, England

[6] Epsom & St Hellier Univ Hosp Trust, Dept Ophthalmol, Carshalton, England

[7] Royal Marsden Natl Hlth Serv NHS Fdn Trust, Dept Pediat Endocrinol, London, England

[8] Royal Marsden Natl Hlth Serv NHS Fdn Trust, Dept Radiotherapy, London, England

来源：

FRONTIERS IN ONCOLOGY | 2023年 / 13卷

关键词：

pediatric diencephalic tumors; glioma; craniopharyngioma; germ cell tumor; Langerhans cell histiocytosis; molecularly targeted therapies; functional outcomes; LANGERHANS CELL HISTIOCYTOSIS; LOW-GRADE GLIOMA; LONG-TERM OUTCOMES; CLINICAL PRESENTATION; SINGLE-INSTITUTION; BRAF MUTATION; YOUNG-ADULTS; PHASE-II; CHILDREN; CRANIOPHARYNGIOMAS;

D O I：

10.3389/fonc.2023.1178553

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pediatric diencephalic tumors represent a histopathologically and molecularly diverse group of neoplasms arising in the central part of the brain and involving eloquent structures, including the hypothalamic-pituitary axis (HPA), optic pathway, thalamus, and pineal gland. Presenting symptoms can include significant neurological, endocrine, or visual manifestations which may be exacerbated by injudicious intervention. Upfront multidisciplinary assessment and coordinated management is crucial from the outset to ensure best short- and long-term functional outcomes. In this review we discuss the clinical and pathological features of the neoplastic entities arising in this location, and their management. We emphasize a clear move towards 'function preserving' diagnostic and therapeutic approaches with novel toxicity-sparing strategies, including targeted therapies.

引用

页数：14

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