Cellular stress in the pathogenesis of nonalcoholic steatohepatitis and liver fibrosis

被引：14

作者：

Sharma, Sachin ^{[1
,2
]}

Le Guillou, Dounia ^{[1
,2
]}

Chen, Jennifer Y. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Ctr Liver, San Francisco, CA 94143 USA

来源：

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2023年 / 20卷 / 10期

关键词：

ENDOPLASMIC-RETICULUM STRESS; HEPATIC STELLATE CELLS; UNFOLDED PROTEIN RESPONSE; SINUSOIDAL ENDOTHELIAL-CELLS; NF-KAPPA-B; FATTY LIVER; OXIDATIVE STRESS; CYTOCHROME-P450; 2E1; NLRP3; INFLAMMASOME; NITRIC-OXIDE;

D O I：

10.1038/s41575-023-00832-w

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The burden of chronic liver disease is rising substantially worldwide. Fibrosis, characterized by excessive deposition of extracellular matrix proteins, is the common pathway leading to cirrhosis, and limited treatment options are available. There is increasing evidence suggesting the role of cellular stress responses contributing to fibrogenesis. This Review provides an overview of studies that analyse the role of cellular stress in different cell types involved in fibrogenesis, including hepatocytes, hepatic stellate cells, liver sinusoidal endothelial cells and macrophages.

引用

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页码：662 / 678

页数：17

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