Dual Disseminated Aspergillosis and Mucormycosis Diagnosed at Autopsy: A Report of Two Cases of Coinfection and a Review of the Literature

被引：5
|
作者：
Murray, Jason [1 ]
Lu, Zhen A. [1 ]
Miller, Karin [2 ]
Meadows, Alex [1 ]
Totten, Marissa [1 ]
Zhang, Sean X. [1 ]
机构：
[1] Johns Hopkins Univ, Dept Pathol, Sch Med, Baltimore, MD 21287 USA
[2] Childrens Hosp Los Angeles, Dept Pathol, Los Angeles, CA 90027 USA
来源：
JOURNAL OF FUNGI | 2023年 / 9卷 / 03期
关键词：
aspergillosis; mucormycosis; coinfection; autopsy; histology; REGION;
D O I：
10.3390/jof9030357
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Coinfection with invasive aspergillosis and mucormycosis in immunocompromised patients has been reported but is rarely confirmed by tissue histology or autopsy. Serum fungal biomarkers and culture are the primary diagnostic tools but are suboptimal for detecting fungal coinfection. Here, we present the cases of two patients who were immunocompromised due to hematologic malignancy where disseminated aspergillosis and mucormycosis coinfection was only diagnosed upon autopsy despite extensive fungal diagnostic workup, and also review recent literature of such instances of coinfection.
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页数：8
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