Pyroptosis and degenerative diseases of the elderly

被引：25
|
作者：
Zhou, Jiamin [1 ,2 ]
Qiu, Jingjing [1 ,2 ]
Song, Yuwan [1 ,2 ]
Liang, Tiantian [1 ,2 ]
Liu, Sha [1 ,2 ]
Ren, Chao [1 ,2 ]
Song, Xicheng [1 ,2 ]
Cui, Limei [1 ,2 ]
Sun, Yan [1 ,2 ]
机构：
[1] Qingdao Univ, Yantai Yuhuangding Hosp, Dept Otolaryngol Head & Neck Surg, Yantai 264000, Shandong, Peoples R China
[2] Shandong Prov Clin Res Ctr, Otorhinolaryngol Dis, Yantai 264000, Shandong, Peoples R China
来源：
CELL DEATH & DISEASE | 2023年 / 14卷 / 02期
关键词：
INTERVERTEBRAL DISC DEGENERATION; NLRP3 INFLAMMASOME ACTIVATION; HEARING-LOSS; CELL-DEATH; MOLECULAR-MECHANISMS; INNER-EAR; TARGET; IL-1-BETA; APOPTOSIS; PATHWAY;
D O I：
10.1038/s41419-023-05634-1
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Pyroptosis is a recently described mechanism of programmed cell death mediated by proteins of the gasdermin family. Widely recognized signaling cascades include the classical, non-classical, caspase-3-dependent gasdermin E and caspase-8-dependent gasdermin D pathways. Additional pyroptotic pathways have been subsequently reported. With the rising prevalence of advanced age, the role of pyroptosis in the degenerative diseases of the elderly has attracted increased research attention. This article reviews the primary mechanisms of pyroptosis and summarizes progress in the research of degenerative diseases of the elderly such as presbycusis, age-related macular degeneration, Alzheimer's disease, intervertebral disc degeneration, and osteoarthritis.
引用
下载
收藏
页数：11
相关论文
共 50 条
  • [21] The role of pyroptosis in inflammatory diseases
    Chai, Rong
    Li, Ying
    Shui, Linna
    Ni, Longxing
    Zhang, Ansheng
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2023, 11
  • [22] Pyroptosis in microbial infectious diseases
    Xiao, Cui
    Cao, Saihong
    Li, Yunfei
    Luo, Yuchen
    Liu, Jian
    Chen, Yuyu
    Bai, Qinqin
    Chen, Lili
    MOLECULAR BIOLOGY REPORTS, 2024, 51 (01)
  • [23] Pyroptosis in inflammatory diseases and cancer
    Rao, Zhiping
    Zhu, Yutong
    Yang, Peng
    Chen, Zhuang
    Xia, Yuqiong
    Qiao, Chaoqiang
    Liu, Weijing
    Deng, Hongzhang
    Li, Jianxiong
    Ning, Pengbo
    Wang, Zhongliang
    THERANOSTICS, 2022, 12 (09): : 4310 - 4329
  • [24] Impact of degenerative spinal diseases on bone mineral density of the lumbar spine in elderly women
    Shigeyuki Muraki
    Seizo Yamamoto
    Hideaki Ishibashi
    Toshiyuki Horiuchi
    Takayuki Hosoi
    Hajime Orimo
    Kozo Nakamura
    Osteoporosis International, 2004, 15 : 724 - 728
  • [25] Embryonic stem cells: New possible therapy for degenerative diseases that affect elderly people
    He, Q
    Li, R
    Bettiol, E
    Jaconi, ME
    JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2003, 58 (03): : 279 - 287
  • [26] Degenerative diseases of the spine
    Schmidt, K. I.
    Viera, J.
    Reith, W.
    RADIOLOGE, 2011, 51 (09): : 779 - 783
  • [27] Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly
    Irizar, Peer Aramillo
    Schaeuble, Sascha
    Esser, Daniela
    Groth, Marco
    Frahm, Christiane
    Priebe, Steffen
    Baumgart, Mario
    Hartmann, Nils
    Marthandan, Shiva
    Menzel, Uwe
    Mueller, Julia
    Schmidt, Silvio
    Ast, Volker
    Caliebe, Amke
    Koenig, Rainer
    Krawczak, Michael
    Ristow, Michael
    Schuster, Stefan
    Cellerino, Alessandro
    Diekmann, Stephan
    Englert, Christoph
    Hemmerich, Peter
    Suehnel, Juergen
    Guthke, Reinhard
    Witte, Otto W.
    Platzer, Matthias
    Ruppin, Eytan
    Kaleta, Christoph
    NATURE COMMUNICATIONS, 2018, 9
  • [28] Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly
    Peer Aramillo Irizar
    Sascha Schäuble
    Daniela Esser
    Marco Groth
    Christiane Frahm
    Steffen Priebe
    Mario Baumgart
    Nils Hartmann
    Shiva Marthandan
    Uwe Menzel
    Jule Müller
    Silvio Schmidt
    Volker Ast
    Amke Caliebe
    Rainer König
    Michael Krawczak
    Michael Ristow
    Stefan Schuster
    Alessandro Cellerino
    Stephan Diekmann
    Christoph Englert
    Peter Hemmerich
    Jürgen Sühnel
    Reinhard Guthke
    Otto W. Witte
    Matthias Platzer
    Eytan Ruppin
    Christoph Kaleta
    Nature Communications, 9
  • [29] Impact of degenerative spinal diseases on bone mineral density of the lumbar spine in elderly women
    Muraki, S
    Yamamoto, S
    Ishibashi, H
    Horiuchi, T
    Hosoi, T
    Orimo, H
    Nakamura, K
    OSTEOPOROSIS INTERNATIONAL, 2004, 15 (09) : 724 - 728
  • [30] Pyroptosis in Steatohepatitis and Liver Diseases
    Knorr, Jana
    Wree, Alexander
    Feldstein, Ariel E.
    JOURNAL OF MOLECULAR BIOLOGY, 2022, 434 (04)
12345