Whole process establishment of carrier-free 177Lu production: from small-scale production to pilot-scale production

被引：2
|
作者：
Yang, Yuchuan [1 ,2 ]
Kan, Wentao [2 ]
Zhuo, Liangang [2 ]
Liu, Xiaojing [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Nucl Sci & Engn, Dong Chuan Rd 800, Shanghai 200240, Peoples R China
[2] China Acad Engn Phys, Inst Nucl Phys & Chem, Mianyang 621999, Sichuan, Peoples R China
来源：
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2023年 / 332卷 / 12期
关键词：
Carrier-free; Lu-177; Production; Small-scale; Pilot-scale; Quality control; SEPARATION;
D O I：
10.1007/s10967-023-09210-x
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
In this research, whole process of small-scale and pilot-scale carrier-free( 177)Lu production have been developed and curie-level Lu-177 was achieved. Additionally, the methodology of product key quality control inspection has been developed and verified, the control standard has been established. Key indicators of the product have met or exceeded the requirements of the European Pharmacopoeia. Up to date, about 30 Ci carrier-free Lu-177 product has been obtained based on this development. The carrier-free Lu-177 obtained in this research has been used in nearly 20 trial parties including units for drug R & D and clinical research.
引用
收藏
页码：4917 / 4928
页数：12
相关论文
共 50 条
  • [31] SMALL-SCALE AGRICULTURAL PRODUCTION IN HUNGARY
    OROS, I
    ACTA OECONOMICA, 1984, 32 (1-2) : 65 - 90
  • [32] THE REBIRTH OF SMALL-SCALE COMMODITY PRODUCTION
    KOROSTELEV, VA
    PROBLEMS OF ECONOMICS, 1988, 31 (08): : 43 - 57
  • [33] SWEDEN AND SMALL-SCALE PRODUCTION OF INVENTIONS
    HELLMAN, LG
    KEMISK TIDSKRIFT, 1973, 85 (11): : 90 - 90
  • [34] Small-scale customization of software production
    Wang Bangjun
    Yang Yang
    Proceedings of the 3rd International Conference on Innovation & Management, Vols 1 and 2, 2006, : 1045 - 1049
  • [35] Effective management of small-scale production
    Iskanderov R.F.
    Frolov E.B.
    Russian Engineering Research, 2011, 31 (12) : 1279 - 1283
  • [36] Method for Small-Scale Production of Deuterochloroform
    Tansukawat, Natha D.
    See, Alyaa E.
    Jiranuntarat, Sadudee
    Corbin, Joshua R.
    Schomaker, Jennifer M.
    JOURNAL OF ORGANIC CHEMISTRY, 2018, 83 (15): : 8739 - 8742
  • [37] Translation of NCA Lu-177 production scale from research to routine
    Hennkens, Heather M.
    Cutler, Cathy S.
    Rotsch, David A.
    Wilder, Stacy L.
    Embree, Mary F.
    Kelsey, James C.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
  • [38] Production Process Performance for Small-Scale Garment Enterprises in Ethiopia
    Hailemariam, Shalemu Sharew
    Gonfa, Firaol Tadese
    INDUSTRIAL ENGINEERING AND MANAGEMENT SYSTEMS, 2024, 23 (01): : 1 - 16
  • [39] Investigation on small-scale low pressure LNG production process
    Ancona, M. A.
    Bianchi, M.
    Branchini, L.
    De Pascale, A.
    Melino, F.
    Mormile, M.
    Palella, M.
    Scarponi, L. B.
    APPLIED ENERGY, 2018, 227 : 672 - 685
  • [40] SMALL-SCALE PRODUCTION OF CRUDE STARCH FROM POTATOES
    MCLEOD, CD
    MISENER, GC
    TRANSACTIONS OF THE ASAE, 1991, 34 (04): : 1592 - 1596
12345