The Singapore National Precision Medicine Strategy

被引：33

作者：

Wong, Eleanor ^{[1
]}

Bertin, Nicolas ^{[1
]}

Hebrard, Maxime ^{[1
]}

Tirado-Magallanes, Roberto ^{[1
]}

Bellis, Claire ^{[1
,2
]}

Lim, Weng Khong ^{[1
,3
,4
,5
]}

Chua, Chee Yong ^{[6
]}

Tong, Philomena Mei Lin ^{[7
]}

Chua, Raymond ^{[7
]}

Mak, Kenneth ^{[7
]}

Lim, Tit Meng ^{[8
]}

Cheong, Wei Yang ^{[7
]}

Thien, Kwee Eng ^{[9
]}

Goh, Khean Teik ^{[7
]}

Chai, Jin-Fang ^{[10
]}

Lee, Jimmy ^{[11
,12
]}

Sung, Joseph Jao-Yiu ^{[12
]}

Wong, Tien Yin ^{[13
]}

Chin, Calvin Woon Loong D. ^{[14
]}

Gluckman, Peter ^{[15
,16
]}

Goh, Liuh Ling ^{[17
]}

Ban, Kenneth Hon Kim ^{[18
,19
]}

Tan, Tin Wee M. ^{[18
,19
]}

Van Dam, Rob M. ^{[35
,36
]}

Teo, Yik Ying ^{[10
]}

Loh, Marie ^{[12
,32
,37
]}

Eillot, Paul ^{[32
]}

Lee, Eng Sing ^{[12
,38
]}

Ngeow, Joanne ^{[39
]}

Riboli, Elio ^{[32
]}

Dalan, Rinkoo ^{[40
]}

Kassam, Irfahan

Lakshmanan, Lakshmi Narayanan

Lim, Tock Han ^{[41
]}

Ng, Hong Kiat

Mina, Theresia

Tay, Darwin

Sabanayagam, Charumathi ^{[42
]}

Tham, Yih Chung ^{[42
]}

Rim, Tyler ^{[42
]}

Aung, Tin ^{[42
]}

Chee, Miao Ling

Li, Hengtong

Chee, Miao Li

Yeo, Khung Keong

Cook, Stuart Alexander

Pua, Chee Jian

Yang, Chengxi

Chong, Yap Seng ^{[43
]}

Eriksson, Johan Gunnar ^{[43
]}

机构：

[1] Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore

[2] Queensland Univ Technol, Ctr Genom & Personalised Hlth, Genom Res Ctr, Sch Biomed Sci, Brisbane, Qld, Australia

[3] SingHealth Duke NUS Inst Precis Med, Singapore, Singapore

[4] SingHealth Duke NUS Genom Med Ctr, Singapore, Singapore

[5] Duke NUS Med Sch, Canc & Stem Cell Biol Program, Singapore, Singapore

[6] Integrated Hlth Informat Syst, Singapore, Singapore

[7] Minist Hlth, Singapore, Singapore

[8] Sci Ctr Singapore, Singapore, Singapore

[9] Sentosa Dev Corp, Singapore, Singapore

[10] Natl Univ Singapore, Natl Univ Hlth Syst, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore

[11] Inst Mental Hlth, Dept Psychosis, Singapore, Singapore

[12] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore

[13] Singapore Eye Res Inst, Singapore Natl Eye Ctr, Singapore, Singapore

[14] Natl Heart Ctr Singapore, Dept Cardiol, Singapore, Singapore

[15] Agcy Sci Technol & Res, Singapore Inst Clin Sci, Singapore, Singapore

[16] Univ Auckland, Liggins Inst, Auckland, New Zealand

[17] Tan Tock Seng Hosp, Personalised Med Serv, Singapore, Singapore

[18] Natl Supercomp Ctr, Singapore, Singapore

[19] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore, Singapore

[20] Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore, Singapore

[21] Natl Univ Singapore, Ctr Innovat & Precis Eye Hlth, Yong Loo Lin Sch Med, Singapore, Singapore

[22] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore, Singapore

[23] Duke NUS Med Sch, Cardiovasc & Metab Disorders Program, Singapore, Singapore

[24] Agcy Sci Technol & Res, Bioinformat Inst, Singapore, Singapore

[25] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore

[26] Natl Univ Singapore, Dept Biol Sci, Singapore, Singapore

[27] Agcy Sci Technol & Res, Inst Infocomm Res, Singapore, Singapore

[28] Inst High Performance Comp, Agcy Sci Technol & Res, Singapore, Singapore

[29] Precis Hlth Res, Singapore, Singapore

[30] Biomed Sci Ind Partnership Off, Singapore, Singapore

[31] Minist Hlth, Chief Hlth Scientists Off, Singapore, Singapore

[32] Imperial Coll London, Sch Publ Hlth Fac Med, Dept Epidemiol & Biostat, London, England

[33] Duke NUS Med Sch, Singapore, Singapore

[34] Natl Univ Singapore, Canc Sci Inst Singapore, Singapore, Singapore

[35] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA

[36] George Washington Univ, Milken Inst Sch Publ Hlth, Exercise & Nutr Sci, Washington, GA USA

[37] Natl Skin Ctr, Singapore, Singapore

[38] Natl Healthcare Grp, Singapore, Singapore

[39] Natl Canc Ctr Singapore, Singapore, Singapore

[40] Tan Tock Seng Hosp, Endocrinol, Singapore, Singapore

[41] Tan Tock Seng Hosp, Ophthalmol, Singapore, Singapore

[42] Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program, Singapore, Singapore

[43] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Obstet & Gynaecol, Singapore, Singapore

[44] KK Womens & Childrens Hosp, Singapore, Singapore

来源：

NATURE GENETICS | 2023年 / 55卷 / 02期

基金：

英国医学研究理事会; 新加坡国家研究基金会;

关键词：

INTEGRATING GENOMICS; COHORT PROFILE; HEALTH; DIVERSITY; SCORES;

D O I：

10.1038/s41588-022-01274-x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

This Perspective article discusses Singapore's efforts to implement a National Precision Medicine Strategy through the integration of genomic, clinical and lifestyle data of up to one million Singaporean individuals. Precision medicine promises to transform healthcare for groups and individuals through early disease detection, refining diagnoses and tailoring treatments. Analysis of large-scale genomic-phenotypic databases is a critical enabler of precision medicine. Although Asia is home to 60% of the world's population, many Asian ancestries are under-represented in existing databases, leading to missed opportunities for new discoveries, particularly for diseases most relevant for these populations. The Singapore National Precision Medicine initiative is a whole-of-government 10-year initiative aiming to generate precision medicine data of up to one million individuals, integrating genomic, lifestyle, health, social and environmental data. Beyond technologies, routine adoption of precision medicine in clinical practice requires social, ethical, legal and regulatory barriers to be addressed. Identifying driver use cases in which precision medicine results in standardized changes to clinical workflows or improvements in population health, coupled with health economic analysis to demonstrate value-based healthcare, is a vital prerequisite for responsible health system adoption.

引用

页码：178 / +

页数：11

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