Senescence Promotes the Recovery of Stemness among Cancer Cells via Reprograming

被引:2
|
作者
Wang, Di [1 ]
Liu, Lingbo [1 ]
机构
[1] Huazhong Univ Sci & Technol, Union Hosp, Inst Hematol, Tongji Med Coll, Wuhan 430022, Peoples R China
基金
中国国家自然科学基金;
关键词
senescence; senescence-associated stemness (SAS); cancer stem cells (CSCs); leukemia stem cells (LSCs); stemness reprograming; senescence-associated secretory phenotype (SASP); therapy-induced senescence (TIS); oncogene-induced senescence (OIS); ACUTE MYELOID-LEUKEMIA; ONCOGENE-INDUCED SENESCENCE; CELLULAR SENESCENCE; MELANOMA-CELLS; IN-VITRO; HETEROGENEITY; CHEMOTHERAPY; RISK; IDENTIFICATION; RESISTANCE;
D O I
10.3390/biom14030288
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Both the senescence of cancer cells and the maintenance of cancer stem cells seem to be mutually exclusive because senescence is considered a physiological mechanism that effectively suppresses tumor growth. Recent studies have revealed common signaling pathways between cellular senescence and the maintenance of stemness in cancer cells, thus challenging the conventional understanding of this process. Although the links between these processes have not yet been fully elucidated, emerging evidence indicates that senescent cancer cells can undergo reprograming to recover stemness. Herein, we provide a comprehensive overview of the close correlation between senescence and stemness reprograming in cancer cells, with a particular focus on the mechanisms by which senescent cancer cells recover their stemness in various tumor systems.
引用
收藏
页数:22
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