Complete hematologic response after belinostat treatment and allogeneic stem cell transplantation for multiple relapsed/refractory angioimmunoblastic T-cell lymphoma: A case report

被引：1
|
作者：
Camus, Vincent [1 ,5 ]
Etancelin, Pascaline [2 ]
Drieux, Fanny [3 ]
Veresezan, Elena-Liana [3 ]
Picquenot, Jean-Michel [3 ]
Penther, Dominique [2 ]
Viennot, Mathieu [4 ]
Ruminy, Philippe [4 ]
Contentin, Nathalie [1 ]
Lemasle, Emilie [1 ]
Lepretre, Stephane [1 ]
Dubois, Sydney [1 ]
Penichoux, Juliette [1 ]
Stamatoullas, Aspasia [1 ]
Zduniak, Alexandra [1 ]
Lanic, Helene [1 ]
Jardin, Fabrice [1 ]
机构：
[1] Ctr Henri Becquerel, Dept Hematol, Rouen, France
[2] Ctr Henri Becquerel, Dept Genet Oncol, Rouen, France
[3] Ctr Henri Becquerel, Dept Pathol, Rouen, France
[4] Ctr Henri Becquerel, INSERM U1245, Rouen, France
[5] Ctr Henri Becquerel, Dept Hematol, Rue Amiens, F-76038 Rouen 1, France
来源：
CLINICAL CASE REPORTS | 2023年 / 11卷 / 06期
关键词：
allogenic stem cell transplantation; belinostat; complete response; HDAC inhibitor; nTFHL-AI; PTCL;
D O I：
10.1002/ccr3.7623
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Key Clinical MessageThis case report highlights the potential of belinostat for the treatment of relapsed/refractory peripheral T-cell lymphomas, for which effective therapies are still scarce. Peripheral T-cell lymphomas have an aggressive disease course associated with poor outcomes. We report a young patient with highly pretreated relapsed/refractory nodal follicular helper T-cell lymphoma (angioimmunoblastic-type [nTFHL-AI]), who successfully received an allogeneic stem cell transplantation following belinostat therapy. The complete hematologic response achieved has lasted more than 2 years.
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页数：10
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