Prenatal Androgen Exposure and Traits of Autism Spectrum Disorder in the Offspring: Odense Child Cohort

被引：5
|
作者：
Palm, Camilla V. B. [1 ,2 ]
Glintborg, Dorte [1 ,2 ]
Find, Laura G. [1 ,2 ,3 ]
Larsen, Pia, V [7 ]
Dalgaard, Cilia M. [1 ,2 ,3 ]
Boye, Henriette [4 ,5 ]
Jensen, Tina K. [4 ,5 ,6 ]
Dreyer, Anja F. [1 ,2 ]
Andersen, Marianne S. [1 ,2 ]
Bilenberg, Niels [2 ,3 ]
机构：
[1] Odense Univ Hosp, Dept Endocrinol & Metab, Klovervaenget 12C, DK-5000 Odense, Denmark
[2] Univ Southern Denmark, Fac Hlth Sci, Dept Clin Res, Winslowspk 19,3rd Floor, DK-5000 Odense, Denmark
[3] Univ Southern Denmark, Dept Child & Adolescent Mental Hlth Odense, Mental Hlth Serv Reg Southern Denmark, JB Winslows Vej 16, DK-5000 Odense, Denmark
[4] Odense Univ Hosp, Hans Christian Andersen Hosp Children & Adolescen, Odense Child Cohort, Klovervaenget 23C, DK-5000 Odense, Denmark
[5] Univ Southern Denmark, OPEN Patient Data Explorat Network OPEN, JB Winslows Vej 9A, DK-5000 Odense, Denmark
[6] Odense Univ Hosp, Dept Environm Med, JB Winslows Vej 17A, DK-5000 Odense, Denmark
[7] Univ Southern Denmark, Mental Hlth Serv Reg Southern Denmark, DK-5000 Odense, Denmark
来源：
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2023年 / 53卷 / 03期
关键词：
Autism spectrum; Prenatal; Testosterone; Birth cohort; POLYCYSTIC-OVARY-SYNDROME; ANOGENITAL DISTANCE; BEHAVIOR CHECKLIST; FREE TESTOSTERONE; PREGNANT-WOMEN; BRAIN; IDENTIFICATION; POPULATION; PRESCHOOLERS; CBCL;
D O I：
10.1007/s10803-022-05446-w
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
Fetal androgen exposure may be associated with autism spectrum disorder (ASD). We studied 1777 mother-child pairs in the prospective Odense Child Cohort. Prenatal androgen exposure was assessed by maternal 3rd trimester testosterone concentrations, maternal polycystic ovary syndrome (PCOS), and 3 months offspring anogenital distance. ASD traits were assessed at age 3 years with the ASD-symptom scale of the Child Behavior Checklist for ages 11/2-5 years. Maternal testosterone was positively associated with traits of ASD in boys (p < 0.05). Maternal PCOS was associated with increased offspring ASD traits (p = 0.046), but became non-significant after excluding parental psychiatric diagnosis. Offspring anogenital distance was not linked to ASD traits. Higher prevalence of ASD in boys could be linked to higher susceptibility to fetal androgen exposure.
引用
收藏
页码：1053 / 1065
页数：13
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