Regulation of follicular T helper cell differentiation in antitumor immunity

被引：6

作者：

Hou, Yueru ^{[1
]}

Cao, Yejin ^{[1
]}

Dong, Lin ^{[1
]}

Huang, Yijin ^{[1
]}

Zhang, Zhiyuan ^{[1
]}

Bi, Yujing ^{[2
,3
]}

Liu, Guangwei ^{[1
,4
]}

机构：

[1] Beijing Normal Univ, Minist Educ, Coll Life Sci, Key Lab Cell Proliferat & Regulat Biol, Beijing, Peoples R China

[2] Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing, Peoples R China

[3] Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China

[4] Beijing Normal Univ, Minist Educ, Coll Life Sci, Key Lab Cell Proliferat & Regulat Biol, Beijing 100875, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CANCER | 2023年 / 153卷 / 02期

关键词：

cancer; helper follicular T cells; humoral immunity; Tfh cells; tumor microenvironment; TERTIARY LYMPHOID STRUCTURES; CXC CHEMOKINE RECEPTOR-5; TGF-BETA; BCL6; COREPRESSOR; EXPRESSION; METHYLATION; METABOLISM; COMPLEX; ICOS;

D O I：

10.1002/ijc.34368

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Follicular T helper (Tfh) cells are a subset of CD4(+) T cells that play an important role in the formation of germinal centers and the maturation and differentiation of affinity-matured B cells. Recent studies have demonstrated important functions of Tfh cells in tertiary lymphoid structures of tumors, revealing great potential of Tfh cells in tumor immunity. However, Tfh development is incompletely understood. The differentiation of Tfh cells is a complex, multistage process regulated at the DNA, RNA and protein levels. This review just summarizes current research on the molecular mechanisms of Tfh cell differentiation to better understand the role of Tfh cells in antitumor immunity.

引用

页码：265 / 277

页数：13

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