Regulating Androgen Receptor Function in Prostate Cancer: Exploring the Diversity of Post-Translational Modifications

被引：2

作者：

Lumahan, Lance Edward V. ^{[1
]}

Arif, Mazia ^{[2
]}

Whitener, Amy E. ^{[2
]}

Yi, Ping ^{[2
]}

机构：

[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77204 USA

[2] Univ Houston, Ctr Nucl Receptors & Cell Signaling, Dept Biol & Biochem, Houston, TX 77205 USA

来源：

CELLS | 2024年 / 13卷 / 02期

关键词：

androgen receptor; post-translational modifications; prostate cancer; acetylation; methylation; phosphorylation; ubiquitination; sumoylation; DEUBIQUITINATING ENZYME USP12; TRANSCRIPTIONAL ACTIVITY; GLUCOCORTICOID-RECEPTOR; DEPENDENT TRANSCRIPTION; COVALENT MODIFICATION; CELL-PROLIFERATION; RESPONSE ELEMENT; BINDING PROTEIN; LIGAND-BINDING; FEEDBACK LOOP;

D O I：

10.3390/cells13020191

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Androgen receptor (AR) transcriptional activity significantly influences prostate cancer (PCa) progression. In addition to ligand stimulation, AR transcriptional activity is also influenced by a variety of post-translational modifications (PTMs). A number of oncogenes and tumor suppressors have been observed leveraging PTMs to influence AR activity. Subjectively targeting these post-translational modifiers based on their impact on PCa cell proliferation is a rapidly developing area of research. This review elucidates the modifiers, contextualizes the effects of these PTMs on AR activity, and connects these cellular interactions to the progression of PCa.

引用

页数：22

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