DNA replication stress and mitotic catastrophe mediate sotorasib addiction in KRASG12C-mutant cancer

被引:0
|
作者
Chiou, Li-Wen
Chan, Chien-Hui
Jhuang, Yu-Ling
Yang, Ching-Yao
Jeng, Yung-Ming
机构
关键词
D O I
10.1158/1538-7445.AM2023-2848
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
2848
引用
收藏
页数:2
相关论文
共 50 条
  • [21] KRASG12c-Mutant NSCLC Under Targeted Therapy in China: Lessons from Eight Cases
    Li, Y.
    Dai, M.
    Zhang, R.
    Nie, X.
    JOURNAL OF THORACIC ONCOLOGY, 2024, 19 (10) : S649 - S649
  • [22] Response to Commentary on "Brief Report: Severe Sotorasib-Related Hepatotoxicity and Non-Liver Adverse Events Associated With Sequential Anti-PD(L)1 and Sotorasib Therapy in KRASG12C-Mutant Lung Cancer"
    Chour, Ali
    Duruisseaux, Michael
    JOURNAL OF THORACIC ONCOLOGY, 2023, 18 (10) : E113 - E114
  • [23] Therapeutic activity of a new KRASG12C inhibitor JMKX001899 in brain metastases: Preclinical models of KRASG12C-mutant non-small cell lung cancer
    He, Danming
    Wang, Jie
    Zhu, Yixiang
    Zhong, Jia
    Bai, Hua
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [24] Sotorasib: a KRASG12C inhibitor for non-small cell lung cancer
    Ganguly, Arghya
    Yoo, Euna
    TRENDS IN PHARMACOLOGICAL SCIENCES, 2022, 43 (06) : 536 - 537
  • [25] Anticancer Efficacy of KRASG12C Inhibitors Is Potentiated by PAK4 Inhibitor KPT9274 in Preclinical Models of KRASG12C-Mutant Pancreatic and Lung Cancers
    Khan, Husain Yar
    Nagasaka, Misako
    Aboukameel, Amro
    Alkhalili, Osama
    Uddin, Md. Hafiz
    Bannoura, Sahar F.
    Mzannar, Yousef
    Azar, Ibrahim
    Beal, Eliza W.
    Tobon, Miguel E.
    Kim, Steve H.
    Beydoun, Rafic
    Baloglu, Erkan
    Senapedis, William
    El-Rayes, Bassel F.
    Philip, Philip A.
    Mohammad, Ramzi M.
    Shields, Anthony F.
    Al Hallak, Mohammed Najeeb
    Azmi, Asfar S.
    MOLECULAR CANCER THERAPEUTICS, 2023, 22 (12) : 1422 - 1433
  • [26] TUSC2 gene therapy in KRASG12C mutant NSCLC overcomes acquired resistance to sotorasib
    Meraz, I.
    Majidi, M.
    Gao, L.
    Ren, C.
    Wu, S.
    Song, R.
    Meng, F.
    Xu, Y.
    Wang, Q.
    Xi, Y.
    Wang, J.
    Jung, S. Y.
    Shpall, E.
    Roth, J. A.
    EUROPEAN JOURNAL OF CANCER, 2024, 211 : S145 - S145
  • [27] Sotorasib-induced liver and non-liver toxicity associated with sequential sotorasib following anti-PD(L)1 in KRASG12C mutant lung cancer
    Chour, A.
    Denis, J.
    Lafitte, C.
    Mascaux, C.
    Zysman, M.
    Lemaitre, A.
    Swalduz, A.
    Gounant, V.
    Cortot, A.
    Darrason, M.
    Cadranel, J.
    Auclin, E.
    Basse, C.
    Tissot, C.
    Decroisette, C.
    Bombaron, P.
    Giroux-Leprieur, E.
    Falchero, L.
    Lebosse, F.
    Duruisseaux, M.
    ANNALS OF ONCOLOGY, 2022, 33 : S49 - S50
  • [28] TEAD inhibition overcomes YAP1/TAZ-driven resistance to RAS inhibitors in KRASG12C-mutant cancers
    Edwards, Alexander C.
    Stalnecker, Clint A.
    Morales, Alexis J.
    Taylor, Khalilah E.
    Hallin, Jill
    Olson, Peter
    Tang, Tracy T.
    Engstrom, Lars
    Post, Leonard
    Christensen, James G.
    Cox, Adrienne D.
    Der, Channing J.
    MOLECULAR CANCER RESEARCH, 2023, 21 (05)
  • [29] Clinical Utility of Circulating Tumor DNA in Patients With Advanced KRASG12C-Mutated NSCLC Treated With Sotorasib
    Ernst, Sophie M.
    van Marion, Ronald
    Atmodimedjo, Peggy N.
    de Jonge, Evert
    Mathijssen, Ron H. J.
    Paats, Marthe S.
    de Bruijn, Peter
    Koolen, Stijn L.
    von der Thuesen, Jan H.
    Aerts, Joachim G. J. V.
    Schaik, Ron H. N. van
    Dubbink, Hendrikus J.
    Dingemans, Anne-Marie C.
    JOURNAL OF THORACIC ONCOLOGY, 2024, 19 (07) : 995 - 1006
  • [30] KRASG12C exhibits allele-specific biology in pancreatic cancer and targeting CD24 sensitizes KRASG12C-driven tumors to sotorasib treatment
    Wei, Yongkun
    Liu, Minghui
    Nguyen, Phuoc T.
    Pan, Dean N.
    Yao, Wantong
    Ying, Haoqiang
    CANCER RESEARCH, 2024, 84 (02)