Recent updates in click and computational chemistry for drug discovery and development

被引：5

作者：

Cai, Jiang Hong ^{[1
]}

Zhu, Xuan Zhe ^{[1
]}

Guo, Peng Yue ^{[2
]}

Rose, Peter ^{[3
]}

Liu, Xiao Tong ^{[1
]}

Liu, Xia ^{[2
]}

Zhu, Yi Zhun ^{[1
,4
]}

机构：

[1] Macau Univ Sci & Technol, Sch Pharm, State Key Lab Qual Res Chinese Med, Taipa, Macau, Peoples R China

[2] Second Mil Univ, Sch Pharm, Dept Clin Pharm, Shanghai, Peoples R China

[3] Univ Nottingham, Sch Biosci, Nottingham, England

[4] Fudan Univ, Sch Pharm, Dept Pharmacol, Shanghai Key Lab Bioact Small Mol, Shanghai, Peoples R China

来源：

FRONTIERS IN CHEMISTRY | 2023年 / 11卷

基金：

中国国家自然科学基金;

关键词：

click chemistry; computational chemistry; CADD; druggable candidates; drug development; THIOL-ENE; HYDROGELS; ANALOGS; DESIGN;

D O I：

10.3389/fchem.2023.1114970

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Drug discovery is a costly and time-consuming process with a very high failure rate. Recently, click chemistry and computer-aided drug design (CADD) represent popular areas for new drug development. Herein, we summarized the recent updates in click and computational chemistry for drug discovery and development including clicking to effectively synthesize druggable candidates, synthesis and modification of natural products, targeted delivery systems, and computer-aided drug discovery for target identification, seeking out and optimizing lead compounds, ADMET prediction as well as compounds synthesis, hopefully, inspires new ideas for novel drug development in the future.

引用

页数：7

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