Effect of Heme Oxygenase-1 Depletion on Complement Regulatory Proteins Expression in the Rat

被引：2
|
作者：
Detsika, Maria G. G. [1 ]
Theochari, Eirini [2 ]
Palamaris, Kostas [2 ]
Gakiopoulou, Harikleia [2 ]
Lianos, Elias A. A. [3 ,4 ]
机构：
[1] Natl & Kapodistrian Univ Athens, Evangelismos Hosp, Dept Crit Care Med 1, Pulm Serv, Athens 10675, Greece
[2] Univ Athens, Sch Med, Dept Pathol, Athens 11527, Greece
[3] Vet Affairs Med Ctr, Salem, VA 24153 USA
[4] Virginia Tech, Carilion Sch Med, Salem, VA 24153 USA
来源：
ANTIOXIDANTS | 2023年 / 12卷 / 01期
关键词：
complement; heme oxygenase (HO)-1; complement regulatory proteins; ACCELERATING FACTOR EXPRESSION; CRRY; KIDNEY; SYSTEM; CELLS;
D O I：
10.3390/antiox12010061
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Heme oxygenase has been implicated in the regulation of various immune responses including complement activation. Using a transgenic rat model of HO-1 depletion, the present study assessed the effect of HO-1 absence on the expression of complement regulatory proteins: decay accelerating factor (DAF), CR1-related gene/protein Y (Crry) and CD59, which act to attenuate complement activation. Protein expression was assessed by immunohistochemistry in kidney, liver, lung and spleen tissues. DAF protein was reduced in all tissues retrieved from rats lacking HO-1 (Hmox1(-/-)) apart from spleen tissue sections. Crry protein was also reduced, but only in Hmox1(-/-) kidney and liver tissue. C3b staining was augmented in the kidney and spleen from Hmox1(-/-) rats, suggesting that the decrease of DAF and Crry was sufficient to increase C3b deposition. The observations support an important role of HO-1 as a regulator of the complement system.
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页数：11
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