Prognostic impact of pretreatment cell-free DNA concentration in newly diagnosed peripheral T-cell lymphomas

被引：0

作者：

Fardella, E. ^{[1
]}

Zanirato, G. ^{[2
]}

Magni, M. ^{[2
]}

Caldarelli, N. ^{[1
]}

Chiappella, A. ^{[2
]}

Dodero, A. ^{[2
]}

Ljevar, S. ^{[3
]}

Orsucci, L. ^{[4
]}

Re, A. ^{[5
]}

Usai, S. V. ^{[6
]}

Stefoni, V. ^{[7
]}

Castellino, C. ^{[8
]}

Rossi, F. G. ^{[9
]}

Pinto, A. ^{[10
]}

Carniti, C. ^{[2
]}

Corradini, P. ^{[1
,2
]}

机构：

[1] Univ Milan, Milan, Italy

[2] Fdn IRCCS Ist Nazl Tumori, Div Hematol & Stem Cell Transplantat, Milan, Italy

[3] Fdn IRCCS Ist Nazl Tumori, Unit Biostat Clin Res, Milan, Italy

[4] Azienda Osped & Univ Citta Salute & Sci, Div Hematol, Turin, Italy

[5] ASST Spedali Civili Brescia, Hematol Div, Brescia, Italy

[6] Osped Oncol Armando Businco, Hematol Unit, Cagliari, Italy

[7] Univ Bologna, Inst Hematol Seragnoli, Bologna, Italy

[8] Azienda Osped S Croce & Carle, Div Hematol, Cuneo, Italy

[9] Fdn IRCCS Ca Granda, Osped Maggiore Policlin, Div Hematol, Milan, Italy

[10] Fdn G Pascale, IRCCS Ist Nazl Tumori, Hematol Oncol & Stem Cell Transplantat Unit, Naples, Italy

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2024年 / 204卷 / 05期

关键词：

DNA prognosis; haematological malignancies; prognostic factors; T-cell lymphoma; CANCER;

D O I：

10.1111/bjh.19280

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Peripheral T-cell lymphomas (PTCLs) have a poor prognosis and, to date, there are no reliable predictive biomarkers of response. In this work we explored the prognostic impact of cell-free DNA (cfDNA) concentration in 75 newly diagnosed patients enrolled in a prospective multicenter study. Pre-treatment cfDNA was strongly associated with clinical risk factors and was identified as a superior predictor for shorter progression-free survival in multivariable analysis, outweighing canonical risk parameters. Furthermore, we identified a cfDNA value above which survival worsens. In conclusion, pre-treatment cfDNA concentration represents an easily usable predictive biomarker that is highly associated with survival of PTCL patients.

引用

页码：1752 / 1756

页数：5

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