Intermittent fasting increases growth differentiation factor 15 in females with overweight or obesity but not associated with food intake

被引：3
|
作者：
Liu, Kai [1 ,2 ]
Liu, Bo [1 ,2 ]
Wittert, Gary A. [1 ,2 ]
Thompson, Campbell H. [1 ]
Hutchison, Amy T. [1 ,2 ]
Heilbronn, Leonie K. [1 ,2 ,3 ]
机构：
[1] Univ Adelaide, Adelaide Med Sch, Adelaide, SA 5000, Australia
[2] South Australian Hlth & Med Res Inst, Lifelong Hlth Theme, Adelaide, SA 5000, Australia
[3] South Australian Hlth & Med Res Inst, Level 7, North Terrace, Adelaide, SA 5000, Australia
来源：
OBESITY RESEARCH & CLINICAL PRACTICE | 2023年 / 17卷 / 01期
基金：
英国医学研究理事会;
关键词：
Growth differentiation factor 15; Intermittent fasting; Calorie restriction; Humans; Female;
D O I：
10.1016/j.orcp.2022.12.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Growth differentiation factor 15 (GDF15) increases with acute fast in animals, and high GDF15 reduces food intake in rodents. We explored whether GDF15 was altered following intermittent fasting (IF) versus caloric restriction (CR), and associations with energy intake. Females with obesity received all foods at 70% (IF70 and CR70) or 100% of energy requirements for 8 weeks. IF ate 2-9% less than provided on refeeding days, resulting in greater weight losses. GDF15 was increased 5% more in IF70 versus CR70, but not associated with energy intake. This rise in GDF15 is unlikely to explain restriction of energy intake during IF.
引用
收藏
页码：91 / 93
页数：3
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