Porous Organic Polymer Supported Nano Ruthenium Catalysts for Cascade Aromatization of Quinoxalin-2(1H)-one and C-H Annulation with Alkynes

被引：4
|
作者：
Huang, Ziwei [1 ]
Xian, Jiayi [1 ]
Lv, Shaohuan [1 ]
Xu, Shanshan [1 ]
Li, Jiefang [1 ]
Xie, Feng [1 ]
Li, Bin [1 ,2 ]
机构：
[1] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Guangdong, Peoples R China
[2] Wuyi Univ, Sch Biotechnol & Hlth Sci, Guangdong Prov Key Lab Large Anim Models Biomed, Jiangmen 529020, Peoples R China
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 44期
关键词：
OXIDATIVE ANNULATION; BOND ACTIVATION; RU; ACCESS;
D O I：
10.1021/acs.orglett.3c03056
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Selective C-H annulation with alkynes is one of the most useful tools to synthesize heterocycles. Herein, we developed novel porous organic polymers supported ruthenium (POPs-Ru) as highly efficient catalysts for cascade aromatization of quinoxalin-2-(1H)-one and C-H annulation with alkynes. Both terminal and internal alkynes were successfully transferred to furo-[2,3-b]-quinoxaline derivatives with good functional group tolerance and high regioselectivity by using POPs-Ru catalysts. Furthermore, the catalyst exhibited high activity and could be reused at least five times without obvious deactivation of this coupling reaction. This study offers an important platform for the immobilization of molecular metal catalysts for C-H functionalization.
引用
收藏
页码：7974 / 7978
页数：5
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