Genetic Markers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease

被引：14
|
作者：
Perumalsamy, Sangeetha [1 ]
Huri, Hasniza Zaman [1 ]
Abdullah, Bashar Mudhaffar [2 ]
Mazlan, Othman [1 ]
Ahmad, Wan Azman Wan [3 ]
Vethakkan, Shireene Ratna D. B. [4 ]
机构：
[1] Univ Malaya, Fac Pharm, Dept Clin Pharm & Pharm Practice, Kuala Lumpur 50603, Malaysia
[2] Al Rafidain Univ Coll, Dept Med Labs Tech, Baghdad, Iraq
[3] Univ Malaya, Fac Med, Dept Med, Cardiol Unit, Kuala Lumpur 50603, Malaysia
[4] Univ Malaya, Fac Med, Dept Med, Endocrinol Unit, Kuala Lumpur 50603, Malaysia
来源：
METABOLITES | 2023年 / 13卷 / 03期
关键词：
insulin resistance; type 2 diabetes mellitus; atherosclerosis; endothelial dysfunction; coronary artery disease; genetic markers; single nucleotide polymorphisms; GENOME-WIDE ASSOCIATION; CD36; GENE; METABOLIC SYNDROME; SERUM-LEVELS; POLYMORPHISM; INTERLEUKIN-18; RISK; VARIANTS; OBESITY; LOCUS;
D O I：
10.3390/metabo13030427
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Type 2 diabetes mellitus (T2DM) is characterized by impaired insulin secretion on a background of insulin resistance (IR). IR and T2DM are associated with atherosclerotic coronary artery disease (CAD). The mechanisms of IR and atherosclerosis are known to share similar genetic and environmental roots. Endothelial dysfunction (ED) detected at the earliest stages of IR might be the origin of atherosclerosis progression. ED influences the secretion of pro-inflammatory cytokines and their encoding genes. The genes and their single nucleotide polymorphisms (SNPs) act as potential genetic markers of IR and atherosclerosis. This review focuses on the link between IR, T2DM, atherosclerosis, CAD, and the potential genetic markers CHI3L1, CD36, LEPR, RETN, IL-18, RBP-4, and RARRES2 genes.
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页数：17
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