Risk of Parkinson's Disease in Celiac Disease: A Swedish Population-Based Study

被引:0
|
作者
Kang, Xiaoying [1 ,2 ]
Ploner, Alexander [1 ]
Roelstraete, Bjorn [1 ]
Ludvigsson, Jonas F. [1 ,3 ]
Wirdefeldt, Karin [1 ,4 ]
机构
[1] Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden
[2] Brigham & Womens Hosp, Dept Neurol, Boston, MA USA
[3] Orebro Univ Hosp, Dept Pediat, Orebro, Sweden
[4] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden
基金
瑞典研究理事会;
关键词
AUTOIMMUNE;
D O I
10.1002/ana.26780
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Using a population-based matched cohort design, we assessed the association of celiac disease (CeD) with risk of PD by comparing patients with biopsy-confirmed CeD in Sweden to a biopsy-free population and their unaffected siblings, separately. No overall association was observed but CeD diagnosed before age 60 associated positively with incident diagnosis of PD (hazard ratio [HR] = 1.29; 95% confidence interval [CI]: 1.02-1.62), which was mainly attributed to the significantly elevated risk detected after 10-15 years since biopsy (HR = 1.68; 95% CI: 1.05-2.68). Our findings imply an increased vulnerability to long-term PD development among patients with CeD diagnosed before 60s. ANN NEUROL 2023
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页码:911 / 916
页数:6
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