Risk of Parkinson's Disease in Celiac Disease: A Swedish Population-Based Study

被引：0

作者：

Kang, Xiaoying ^{[1
,2
]}

Ploner, Alexander ^{[1
]}

Roelstraete, Bjorn ^{[1
]}

Ludvigsson, Jonas F. ^{[1
,3
]}

Wirdefeldt, Karin ^{[1
,4
]}

机构：

[1] Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden

[2] Brigham & Womens Hosp, Dept Neurol, Boston, MA USA

[3] Orebro Univ Hosp, Dept Pediat, Orebro, Sweden

[4] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

来源：

ANNALS OF NEUROLOGY | 2023年 / 94卷 / 05期

基金：

瑞典研究理事会;

关键词：

AUTOIMMUNE;

D O I：

10.1002/ana.26780

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Using a population-based matched cohort design, we assessed the association of celiac disease (CeD) with risk of PD by comparing patients with biopsy-confirmed CeD in Sweden to a biopsy-free population and their unaffected siblings, separately. No overall association was observed but CeD diagnosed before age 60 associated positively with incident diagnosis of PD (hazard ratio [HR] = 1.29; 95% confidence interval [CI]: 1.02-1.62), which was mainly attributed to the significantly elevated risk detected after 10-15 years since biopsy (HR = 1.68; 95% CI: 1.05-2.68). Our findings imply an increased vulnerability to long-term PD development among patients with CeD diagnosed before 60s. ANN NEUROL 2023

引用

页码：911 / 916

页数：6

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