Isoflavones-functionalized single-walled and multi-walled carbon nanotubes: Synthesis and characterization of new nanoarchitetonics for biomedical uses

In this work, we describe the functionalization of single-walled carbon nanotubes (SWCNTs) and multiple-walled carbon nanotubes (MWCNTs) with two selected isoflavones (biochanin A and formononetin), and compare the physicochemical properties of the obtained assemblies. The selection of isoflavones was based on the preliminary assessment of bibliometric maps generated from Scopus core collection. Acidic treatment of SWCNTs and MWCNTs improved the samples' dispersibility in water. Regardless the pH environment, SWCNTs remained aggregated in aqueous solution, even after functionalization. The dispersibility of MWCNT increased after acidic treatment (MWCNTA) in both tested pH values (4 and 7). Functionalization was confirmed by the improved dispersibility of CNTs with both isoflavones. MWNCTA and isoflavone 1:1 (w/w) was used for both molecules. Biochanin A showed improved anchoring in MWNCTA when compared to formononetin. Our results corroborate the interest on the use of these new biomaterials based on carbon nanotubes for a range of biomedical applications.