Pharmacotherapy for obsessive-compulsive disorder: Real-world evidence from a 10-year retrospective data analysis

被引：0
|
作者：
Oh, Sanghoon [1 ,2 ]
Cho, Sunwoo [3 ]
Moon, Sun-Young [4 ]
Lee, Junhee [2 ]
Kim, Minah [5 ]
Lee, Tae Young [6 ]
Kwon, Jun Soo [1 ,5 ,7 ,8 ,9 ]
机构：
[1] Seoul Natl Univ, Coll Med, Dept Psychiat, Seoul, South Korea
[2] Eulji Univ, Uijeongbu Eulji Med Ctr, Dept Psychiat, Sch Med, Daejeon, Gyeonggi Do, South Korea
[3] Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC USA
[4] Seoul Natl Univ, Bundang Hosp, Dept Neuropsychiat, Songnam, Gyeonggi Do, South Korea
[5] Seoul Natl Univ Hosp, Dept Neuropsychiat, Seoul, South Korea
[6] Pusan Natl Univ, Yangsan Hosp, Dept Neuropsychiat, Yangsan, South Korea
[7] Seoul Natl Univ, Coll Nat Sci, Dept Brain & Cognit Sci, Seoul, South Korea
[8] Seoul Natl Univ, Med Res Ctr, Inst Human Behav Med, Seoul, South Korea
[9] Seoul Natl Univ, Dept Psychiat, Coll Med, 101 Daehak Ro, Seoul 03080, South Korea
来源：
ASIAN JOURNAL OF PSYCHIATRY | 2024年 / 91卷
关键词：
Obsessive -compulsive disorder; Pharmacotherapy; Real -world prescription patterns; Comorbidity; Treatment guidelines; POSTTRAUMATIC-STRESS-DISORDER; LONG-TERM TREATMENT; PHARMACOLOGICAL-TREATMENT; ANXIETY DISORDERS; COMORBIDITY; GUIDELINES; IMPACT; BENZODIAZEPINES; STRATEGIES;
D O I：
10.1016/j.ajp.2023.103847
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
We investigated pharmacotherapy trends for obsessive-compulsive disorder (OCD) patients at a Korean tertiary hospital from 2008 to 2017. Out of 1894 patients, 82.9% received at least one psychotropic medication, with prescription rates increasing over time. The most frequently prescribed drug classes were selective serotonin reuptake inhibitors (SSRIs, 80.5%), anxiolytics (57.5%), antipsychotics (47.2%), other antidepressants (21.1%), and mood stabilizers (18.4%). Combination therapy was administered to 79.7% of medicated patients, with SSRIs, anxiolytics, and antipsychotics being the most common combination. Comorbidities significantly increased the prescription rates of all psychotropic classes (P < 0.001). Our study offers insights that may aid in bridging the gap between OCD treatment guidelines and real-world clinical practice.
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页数：5
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