Inactivation of catalytic and non-catalytic PI3-kinase gamma function enhances hypoxia-induced pulmonary hypertension in mice

被引:0
|
作者
Gnatzy-Feik, L. [1 ]
Berghausen, E. [1 ]
Vantler, M. [1 ]
Mueller, R. [1 ]
Zierden, M. [1 ]
Ghigo, A. [2 ]
Hirsch, E. [2 ]
Baldus, S. [1 ]
Rosenkranz, S. [1 ]
机构
[1] Univ Cologne, Heart Ctr, Cologne, Germany
[2] Univ Turin, Dept Mol Biotechnol & Hlth Sci, Turin, Italy
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:1
相关论文
共 50 条
  • [31] Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL17/G-CSF axis and induces neutrophilia
    Bucher, Kirsten
    Schmitt, Fee
    Mothes, Benedikt
    Blumendeller, Carolin
    Schaell, Daniel
    Piekorz, Roland
    Hirsch, Emilio
    Nuernberg, Bernd
    Beer-Hammer, Sandra
    CELL COMMUNICATION AND SIGNALING, 2017, 15
  • [32] Deletion of classical transient receptor potential 1, 3 and 6 alters pulmonary vasoconstriction in chronic hypoxia-induced pulmonary hypertension in mice
    Malkmus, Kathrin
    Brosien, Monika
    Knoepp, Fenja
    Schaffelhofer, Lisa
    Grimminger, Friedrich
    Rummel, Christoph
    Gudermann, Thomas
    Dietrich, Alexander
    Birnbaumer, Lutz
    Weissmann, Norbert
    Kraut, Simone
    FRONTIERS IN PHYSIOLOGY, 2022, 13
  • [33] Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice: Partial dependence on endothelial NO synthase
    Abe, K
    Uwatoku, T
    Oi, K
    Hizume, T
    Shimokawa, H
    CIRCULATION, 2004, 110 (17) : 132 - 132
  • [34] RETRACTED: Mice lacking the Raf-1 kinase inhibitor protein exhibit exaggerated hypoxia-induced pulmonary hypertension (Retracted Article)
    Morecroft, I.
    Doyle, B.
    Nilsen, M.
    Kolch, W.
    Mair, K.
    MacLean, M. R.
    BRITISH JOURNAL OF PHARMACOLOGY, 2011, 163 (05) : 948 - 963
  • [35] Suppression of Phosphatidylinositol 3-Kinase/Akt Signaling Attenuates Hypoxia-Induced Pulmonary Hypertension Through the Downregulation of Lysyl Oxidase
    Xia, Xiao-Dong
    Lee, Jasmine
    Khan, Sajid
    Ye, Leping
    Li, Yuan
    Dong, Liang
    DNA AND CELL BIOLOGY, 2016, 35 (10) : 599 - 606
  • [36] Disruption of βPDGF Receptor-Dependent PI3k and Plcγ Signaling Protects from Hypoxia-Induced Pulmonary Hypertension
    Ten Freyhaus, Henrik
    Janssen, Wiebke
    Leuchs, Maike
    Zierden, Mario
    Berghausen, Eva
    Vantler, Marius
    Caglayan, Evren
    Schermuly, Ralph T.
    Tallquist, Michelle D.
    Rosenkranz, Stephan
    CIRCULATION, 2012, 126 (21)
  • [37] Rare variants In RNF2I3, a susceptibility gene for moyamoya disease, are found in patients with pulmonary hypertension and aggravate hypoxia-induced pulmonary hypertension in mice
    Kobayashi, Hatasu
    Kabata, Risako
    Kinoshita, Hideyuki
    Morimoto, Takaaki
    Ono, Koh
    Takeda, Midori
    Choi, Jungmi
    Okuda, Hiroko
    Liu, Wanyang
    Harada, Kouji H.
    Kimura, Takeshi
    Youssefian, Shohab
    Koizumi, Akio
    PULMONARY CIRCULATION, 2018, 8 (03)
  • [38] Endothelial 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase, Isoform 3 (PFKFB3) Deficiency Inhibits Hypoxia-Induced Pulmonary Hypertension in Mice
    Cao, Yapeng
    Yang, Qiuhua
    Wang, Lina
    Xu, Jiean
    Liu, Zhiping
    Xu, Yiming
    Wang, Yong
    Fulton, David J.
    Weintraub, Neal L.
    Wu, Chaodong
    Li, Qinkai
    Su, Yunchao
    Hong, Mei
    Huo, Yuqing
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2018, 38
  • [39] Endothelial 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase, Isoform 3 (PFKFB3) Deficiency Inhibits Hypoxia-Induced Pulmonary Hypertension in Mice
    Can, Yapeng
    Yang, Qiuhua
    Wang, Lina
    Xu, Jiean
    Liu, Zhiping
    Xu, Yiming
    Wang, Yong
    Fulton, David J.
    Weintraub, Neal L.
    Wu, Chaodong
    Li, Qinkai
    Su, Yunchao
    Hong, Mei
    Huo, Yuqing
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2018, 38
  • [40] Protection against hypoxia-induced pulmonary hypertension in CX3CR1-deficient mice correlates with decreased microglia activation
    Oliveira, Aline Cristina
    Aquino, Victor
    Sharma, Ravindra K.
    Lobaton, Gilberto
    Harrison, Jeffrey K.
    Richards, Elaine M.
    Raizada, Mohan K.
    FASEB JOURNAL, 2018, 32 (01):