Influence of polymorphisms in CYP2C9, VKORC1, MDR1 and APOE genes on the warfarin maintenance dose in Brazilian patients

被引：1
|
作者：
Campos, Emilio Itamar de Freitas [1 ]
Gomes, Karina Braga [2 ]
Ribeiro, Daniel Dias [3 ]
Puurunen, Marja Kaarina [4 ]
Mourao, Aline deOliveira Magalhaes [1 ]
Ferreira, Isadora Goncalves [2 ]
Rocha, Manoel Otavio da Costa [1 ,3 ]
de Souza, Renan Pedra [5 ]
Martins, Maria Auxiliadora Parreiras [1 ,2 ,3 ]
机构：
[1] Univ Fed Minas Gerais, Fac Med, Ave Prof Alfredo Balena 190, BR-30130100 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Fac Farm, Ave Pres Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil
[3] Univ Fed Minas Gerais, Hosp Clin, Ave Prof Alfredo Balena 110, BR-30130100 Belo Horizonte, MG, Brazil
[4] Boston Univ, 73 Mt Wayte Ave,Suite 2, Framingham, MA 01702 USA
[5] Univ Fed Minas Gerais, Inst Ciencias Biol, Ave Pres Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil
来源：
PHARMACOGENOMICS | 2023年 / 24卷 / 13期
关键词：
APOE; genetic polymorphism; MDR1; VKORC1; warfarin; DOSING ALGORITHM; C3435T POLYMORPHISM; ORAL ANTICOAGULANT; REQUIREMENTS; DOSAGE; SUSCEPTIBILITY; SENSITIVITY; POPULATION; INTENSITY; GENOTYPE;
D O I：
10.2217/pgs-2023-0099
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Background: Polymorphisms in the CYP2C9, VKORC1, MDR1 and APOE genes may impact warfarin dose. Aim: To investigate the influence of sociodemographic and clinical factors and polymorphisms *1, *2 and *3 for CYP2C9, -1639G > A for VKORC1, 3435C > T for MDR1, and epsilon 2, epsilon 3 and epsilon 4 for APOE genes on the mean weekly warfarin maintenance dose in adults. Methods: This cross-sectional study recruited a calculated sample of 315 patients in three anticoagulation clinics in Brazil. A model containing the variables significantly associated with warfarin dose was estimated. Results: Themean age of patients was 64.1 +/- 13.1 years, with 173 (54.9%) women. Age, use of amiodarone, genotype VKORC1 GA, genotype VKORC1 AA, genotypes CYP2C9*1/*2 or *1/*3 and genotypes CYP2C9*2/*2 or *2/*3 or *3/*3 were associated with a reduced warfarin dose. Conclusion: This study pointed out factors that could impact the management of oral anticoagulation.
引用
收藏
页码：701 / 712
页数：12
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