Cross-sectional and longitudinal neuroanatomical profiles of distinct clinical (adaptive) outcomes in autism

被引：3

作者：

Pretzsch, Charlotte ^{[1
]}

Floris, Dorothea ^{[2
,3
]}

Schaefer, Tim V. ^{[4
]}

Bletsch, Anke H. ^{[4
]}

Gurr, Caroline ^{[4
]}

Lombardo, Michael ^{[5
]}

Chatham, Chris ^{[6
]}

Tillmann, Julian ^{[6
]}

Charman, Tony ^{[7
]}

Arenella, Martina ^{[1
,8
]}

Jones, Emily ^{[9
]}

Ambrosino, Sara ^{[10
]}

Bourgeron, Thomas S. ^{[11
]}

Dumas, Guillaume ^{[12
]}

Cliquet, Freddy ^{[11
]}

Leblond, Claire K. ^{[11
]}

Loth, Eva ^{[1
]}

Oakley, Bethany F. ^{[1
]}

Buitelaar, Jan M. ^{[3
]}

Baron-Cohen, Simon ^{[13
]}

Beckmann, Christian ^{[3
]}

Persico, Antonio M. ^{[14
]}

Banaschewski, Tobias ^{[15
]}

Durston, Sarah ^{[10
]}

Freitag, Christine ^{[4
]}

Murphy, Declan G. M. ^{[4
]}

Ecker, Christine ^{[4
]}

机构：

[1] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Forens & Neurodev Sci, London, England

[2] Univ Zurich, Dept Psychol, Methods Plast Res, Zurich, Switzerland

[3] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Med Ctr, Dept Cognit Neurosci, Nijmegen, Netherlands

[4] Goethe Univ Frankfurt, Univ Hosp Frankfurt, Dept Child & Adolescent Psychiat Psychosomat & Psy, Frankfurt, Germany

[5] Ist Italiano Tecnol, Ctr Neurosci & Cognit Syst UniTn, Lab Autism & Neurodev Disorders, Rovereto, Italy

[6] Innovat Ctr Basel, F Hoffmann Roche, Basel, Switzerland

[7] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol, Clin Child Psychol, London, England

[8] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, Nijmegen, Netherlands

[9] Univ London, Ctr Brain & Cognit Dev, London, England

[10] Univ Utrecht, Univ Med Ctr Utrecht, Utrecht, Netherlands

[11] Univ Paris Cite, Inst Pasteur, Human Genet & Cognit Funct, CNRS UMR3571,IUF, Paris, France

[12] Univ Montreal, CHU Sainte Justine Res Ctr, Dept Psychiat, Montreal, PQ, Canada

[13] Univ Cambridge, Autism Res Ctr, Dept Psychiat, Cambridge, England

[14] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, Child & Adolescent Neuropsychiat, Modena, Italy

[15] Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Child & Adolescent Psychiat, Mannheim, Germany

来源：

MOLECULAR PSYCHIATRY | 2023年 / 28卷 / 05期

关键词：

SPECTRUM DISORDER; ANTERIOR CINGULATE; REPETITIVE BEHAVIOR; CHILDREN; LANGUAGE; ADULTS; INDIVIDUALS; ADOLESCENTS; THICKNESS; RESPONSES;

D O I：

10.1038/s41380-023-02016-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Individuals with autism spectrum disorder (henceforth referred to as autism) display significant variation in clinical outcome. For instance, across age, some individuals' adaptive skills naturally improve or remain stable, while others' decrease. To pave the way for 'precision-medicine' approaches, it is crucial to identify the cross-sectional and, given the developmental nature of autism, longitudinal neurobiological (including neuroanatomical and linked genetic) correlates of this variation. We conducted a longitudinal follow-up study of 333 individuals (161 autistic and 172 neurotypical individuals, aged 6-30 years), with two assessment time points separated by similar to 12-24 months. We collected behavioural (Vineland Adaptive Behaviour Scale-II, VABS-II) and neuroanatomical (structural magnetic resonance imaging) data. Autistic participants were grouped into clinically meaningful "Increasers", "No-changers", and "Decreasers" in adaptive behaviour (based on VABS-II scores). We compared each clinical subgroup's neuroanatomy (surface area and cortical thickness at T1, increment T (intra-individual change) and T2) to that of the neurotypicals. Next, we explored the neuroanatomical differences' potential genomic associates using the Allen Human Brain Atlas. Clinical subgroups had distinct neuroanatomical profiles in surface area and cortical thickness at baseline, neuroanatomical development, and follow-up. These profiles were enriched for genes previously associated with autism and for genes previously linked to neurobiological pathways implicated in autism (e.g. excitation-inhibition systems). Our findings suggest that distinct clinical outcomes (i.e. intra-individual change in clinical profiles) linked to autism core symptoms are associated with atypical cross-sectional and longitudinal, i.e. developmental, neurobiological profiles. If validated, our findings may advance the development of interventions, e.g. targeting mechanisms linked to relatively poorer outcomes.

引用

页码：2158 / 2169

页数：12

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