Rh(III)-Catalyzed [4+1] Annulation of Benzamides with Vinyl Cyclic Carbonates for the Synthesis of Isoindolinones

被引：4

作者：

Li, Xiang ^{[1
]}

Cheng, Hang ^{[1
]}

Shao, Jianghao ^{[1
]}

Zhang, Guodong ^{[2
]}

Zhang, Shuilong ^{[3
]}

机构：

[1] Shaanxi Univ Sci & Technol, Coll Chem & Chem Engn, Shaanxi Key Lab Chem Addit Ind, Xian 710021, Shaanxi, Peoples R China

[2] Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou, Jiangsu, Peoples R China

[3] Shanghai Xchemtech Co Ltd, Shanghai 201611, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 07期

关键词：

D O I：

10.1021/acs.orglett.3c03899

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Rh(III)-catalyzed C-H bond activation and subsequent [4+1] annulation of benzamides with vinyl cyclic carbonates have been developed for the synthesis of isoindolinones, in which the electron-rich alkenes could serve as one-carbon units. This reaction proceeds smoothly with high regioselectivity under oxidant- and silver-free conditions and exhibits broad substrate scope and functional group tolerance including some biological active materials. The scale-up reaction and derivatizations of the product further demonstrate the potential synthetic utility of this transformation.

引用

页码：1304 / 1309

页数：6

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