Targeting HDAC9 Contributes to Degradation of MLL Fusion Oncoproteins in KMT2A-Rearranged Acute Myeloid Leukemia

被引：0
|
作者：
Zhou, Yutong [1 ]
Qian, Yu [1 ]
Jin, Jie [1 ]
机构：
[1] Zhejiang Univ, Affiliated Hosp 1, Dept Hematol, Sch Med, Hangzhou, Peoples R China
来源：
BLOOD | 2023年 / 142卷
关键词：
D O I：
10.1182/blood-2023-185947
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页数：3
相关论文
共 50 条
  • [31] Case Report: Targeting 2 Antigens as a Promising Strategy in Mixed Phenotype Acute Leukemia: Combination of Blinatumomab With Gemtuzumab Ozogamicin in an Infant With a KMT2A-Rearranged Leukemia
    Brethon, Benoit
    Lainey, Elodie
    Caye-Eude, Aurelie
    Grain, Audrey
    Fenneteau, Odile
    Yakouben, Karima
    Roupret-Serzec, Julie
    Le Mouel, Lou
    Cave, Helene
    Baruchel, Andre
    FRONTIERS IN ONCOLOGY, 2021, 11
  • [32] DYRK1A Is Required to Alleviate Replication Stress in KMT2A-Rearranged Acute Lymphoblastic Leukemia
    Hurtz, Christian
    Carroll, Martin P.
    Tasian, Sarah K.
    Wertheim, Gerald
    Bhansali, Rahul S.
    Lee, Sung June
    Kumar, Anil
    Lehman, Anne
    Loftus, Joseph Patrick
    Jeschke, Grace
    Crispino, John D.
    Besson, Thierry
    Shi, Junwei
    Swaminathan, Srividya
    BLOOD, 2020, 136
  • [33] Menin Inhibition With Revumenib for KMT2A-Rearranged Relapsed or Refractory Acute Leukemia (AUGMENT-101)
    Issa, Ghayas C.
    Aldoss, Ibrahim
    Thirman, Michael J.
    Dipersio, John
    Arellano, Martha
    Blachly, James S.
    Mannis, Gabriel N.
    Perl, Alexander
    Dickens, David S.
    Mcmahon, Christine M.
    Traer, Elie
    Zwaan, C. Michel
    Grove, Carolyn S.
    Stone, Richard
    Shami, Paul J.
    Mantzaris, Ioannis
    Greenwood, Matthew
    Shukla, Neerav
    Cuglievan, Branko
    Kovacsovics, Tibor
    Gu, Yu
    Bagley, Rebecca G.
    Madigan, Kate
    Chudnovsky, Yakov
    Nguyen, Huy Van
    Mcneer, Nicole
    Stein, Eytan M.
    JOURNAL OF CLINICAL ONCOLOGY, 2025, 43 (01)
  • [34] Clinical experience with venetoclax and hypomethylating agents (HMA) in patients with newly diagnosed and relapsed or refractory KMT2A-Rearranged acute myeloid leukemia (AML)
    Ball, Brian J.
    Arslan, Shukaib
    Koller, Paul
    Ngo, Dat
    Afkhami, Michelle
    Salhotra, Amandeep
    Al-Malki, Monzr
    Aribi, Ahmed
    Ali, Haris
    Sandhu, Karamjeet
    Otoukesh, Salman
    Amanam, Idoroenyi
    Pourhassan, Hoda
    Artz, Andrew
    Curtin, Peter
    Stein, Anthony
    Nakamura, Ryotaro
    Marcucci, Guido
    Smith, Eileen
    Pullarkat, Vinod
    Aldoss, Ibrahim
    LEUKEMIA & LYMPHOMA, 2022, 63 (13) : 3232 - 3236
  • [35] MLL2 PROMOTES CELL SURVIVAL IN MLL1-REARRANGED ACUTE MYELOID LEUKEMIA
    不详
    CANCER DISCOVERY, 2017, 7 (08) : 795 - 795
  • [36] Methionine Restriction As a Novel Therapeutic Strategy for MLL (KMT2A)Rearranged Acute Lymphoblastic Leukemia
    Tee, Trisha
    Riter, Titine
    Dhaoui, Ahmed
    Schenau, Dorettevan Ingen
    Hagelaar, Rico
    der Meer, Laurensvan
    Leeuwen, Frankvan
    BLOOD, 2021, 138
  • [37] Intensification of Early-Phase Therapy to Diminish the Prognostic Effect of Myeloid Antigen Expression in Infants with KMT2A-Rearranged Acute Lymphoblastic Leukemia: A Report from the JPLSG MLL-10 Trial
    Arakawa, Yuki
    Ishihara, Takashi
    Miyamura, Takako
    Deguchi, Takao
    Sanada, Masashi
    Hori, Toshinori
    Yamada, Tomomi
    Aoki, Yuki
    Ishimaru, Sae
    Takachi, Takayuki
    Yano, Mio
    Sasaki, Shinya
    Saito, Akiko M.
    Manabe, Atsushi
    Horibe, Keizo
    Imamura, Toshihiko
    Tomizawa, Daisuke
    BLOOD, 2021, 138
  • [38] Drug Repurposing for Targeting Acute Leukemia With KMT2A (MLL)-Gene Rearrangements
    Tsakaneli, Alexia
    Williams, Owen
    FRONTIERS IN PHARMACOLOGY, 2021, 12
  • [39] Novel MLL/KMT2A-MON2 fusion in a child with therapy-related acute myeloid leukemia after treatment for acute promyelocytic leukemia
    Gong, Yanlei
    Wang, Man
    Shen, Hongjie
    Chen, Yan
    Cen, Jiannong
    Yin, Xiaolin
    Yao, Li
    MOLECULAR CARCINOGENESIS, 2021, 60 (11) : 721 - 725
  • [40] Lineage switch from B lymphoblastic leukemia with KMT2A-rearranged to mixed-phenotype acute leukemia under daratumumab
    Marco-Ayala, Javier
    Isabel Vicente, Ana
    Such, Esperanza
    Luna, Irene
    Andreu, Rafael
    Sempere, Amparo
    Romero, Samuel
    Senent Peris, Maria Leonor
    BLOOD RESEARCH, 2020, 55 (02) : 75 - 75
12345