Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action

被引：24

作者：

Mirza, Fatima Javed ^{[1
,2
]}

Zahid, Saadia ^{[2
]}

Holsinger, R. M. Damian ^{[1
,3
]}

机构：

[1] Univ Sydney, Fac Med & Hlth, Sch Med Sci, Lab Mol Neurosci & Dementia, Camperdown, NSW 2050, Australia

[2] Natl Univ Sci & Technol, Atta ur Rahman Sch Appl Biosci, Dept Healthcare Biotechnol, Neurobiol Res Lab, Islamabad 44000, Pakistan

[3] Univ Sydney, Fac Med & Hlth, Sch Med Sci, Neurosci, Sydney, NSW 2006, Australia

来源：

MOLECULES | 2023年 / 28卷 / 05期

关键词：

neuroprotection; carnosic acid; natural sources; neurodegeneration; autophagy; oxidative stress; apoptosis; Keap1; Nrf2; signaling; AMYLOID PRECURSOR PROTEIN; 6-HYDROXYDOPAMINE-INDUCED CELL-DEATH; NEUROBLASTOMA SH-SY5Y CELLS; ROSMARINUS-OFFICINALIS L; GLUTATHIONE-S-TRANSFERASE; ALZHEIMERS-DISEASE; MITOCHONDRIAL DYSFUNCTION; OXIDATIVE STRESS; BRAIN-INJURY; BETA; 1-42;

D O I：

10.3390/molecules28052306

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Carnosic acid is a diterpenoid abundantly present in plants belonging to the genus Rosmarinus and Salvia of the family Lamiaceae, accounting for their application in traditional medicine. The diverse biological properties of carnosic acid that include antioxidant, anti-inflammatory, and anticarcinogenic activities have instigated studies on its mechanistic role, providing further insights into its potential as a therapeutic agent. Accumulating evidence has established the relevance of carnosic acid as a neuroprotective agent exhibiting therapeutic efficacy in combatting neuronal-injury-induced disorders. The physiological importance of carnosic acid in the mitigation of neurodegenerative disorders is just beginning to be understood. This review summarizes the current data on the mode of action through which carnosic acid exerts its neuroprotective role that may serve to strategize novel therapeutic approaches for these debilitating neurodegenerative disorders.

引用

页数：13

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