A modified IL-18 drug in combination with CTLA-4 blockade enhances anti-tumor efficacy in preclinical models of renal cell carcinoma

被引:0
|
作者
Schoenfeld, David [1 ]
Djureinovic, Dijana [1 ]
Zhang, Lin [1 ]
Mann, Jacqueline [1 ]
Huck, John [2 ]
Jilaveanu, Lucia [1 ]
Ring, Aaron [2 ]
Kluger, Harriet [1 ]
机构
[1] Yale Sch Med, Sect Med Oncol, New Haven, CT USA
[2] Yale Sch Med, Dept Immunobiol, New Haven, CT USA
来源
ONCOLOGIST | 2023年 / 28卷
关键词
IL-18; cytokines; immune-checkpoint inhibitors; anti-CTLA-4; preclinical models; RCC;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
58
引用
收藏
页码:S7 / S7
页数:1
相关论文
共 50 条
  • [21] Combination of CTLA-4 blockade with MUC1 mRNA nanovaccine induces enhanced anti-tumor CTL activity by modulating tumor microenvironment of triple negative breast cancer
    Lin, Xuan
    Chen, Hedan
    Xie, Ying
    Zhou, Xue
    Wang, Yun
    Zhou, Jing
    Long, Shiqi
    Hu, Zuquan
    Zhang, Shichao
    Qiu, Wei
    Zeng, Zhu
    Liu, Lina
    TRANSLATIONAL ONCOLOGY, 2022, 15 (01):
  • [22] PD-1 blockade enhances the anti-tumor immune response induced by cryoablation in a murine model of renal cell carcinoma
    Zhu, Chenzhuang
    Lin, Sihao
    Liang, Junhao
    Zhu, Yingjian
    CRYOBIOLOGY, 2019, 87 : 86 - 90
  • [23] MAP4K1 inhibition enhances immune cell activation and anti-tumor immunity in preclinical tumor models.
    Faia, Kerrie
    Toso, Alberto
    Fetalvero, Kristina
    Roche, Marly
    Bench, Steven
    O'Hearn, Erin
    Cao, Qiongfang
    Bright, Kerry-Ann
    Paduraru, Debora
    Romagnani, Andrea
    Weng, Weifan
    Zimmermann, Tina
    Burke, Michael
    Close, Joshua
    Green, Luke
    Kim, Joseph
    Miduturu, Chandra
    Ribeiro, Alison
    Bacac, Marina
    Herter, Sylvia
    Perola, Emanuele
    Sheets, Michael
    Eckmann, Jan
    Heidkamp, Gordon
    Traore, Tary
    Gerson, Erik
    Woessner, Rich
    Wolter, Carsten
    Scheuplein, Felix
    Perez, Nisha
    LaBranche, Timothy
    Silva, Grace
    Ye, Chaoyang
    Utt, Caitlin
    Gross, Stefan
    Bischoff, James R.
    Dorsch, Marion
    Guzi, Tim
    Hoeflich, Klaus
    Brubaker, Jason
    CANCER RESEARCH, 2021, 81 (13)
  • [24] A CTLA-4 blocking strategy based on Nanoboby in dendritic cell-stimulated cytokine-induced killer cells enhances their anti-tumor effects
    Wang, Wu
    Wang, Xi
    Yang, Wenli
    Zhong, Kai
    He, Na
    Li, Xuexia
    Pang, Yanyang
    Lu, Zi
    Liu, Aiqun
    Lu, Xiaoling
    BMC CANCER, 2021, 21 (01)
  • [25] A CTLA-4 blocking strategy based on Nanobody in dendritic cell-stimulated cytokine-induced killer cells enhances their anti-tumor effects
    Wu Wang
    Xi Wang
    Wenli Yang
    Kai Zhong
    Na He
    Xuexia Li
    Yanyang Pang
    Zi Lu
    Aiqun Liu
    Xiaoling Lu
    BMC Cancer, 21
  • [26] The Combination of Anti-CD47 Antibody with CTLA4 Blockade Enhances Anti-Tumor Immunity in Non-Small Cell Lung Cancer via Normalization of Tumor Vasculature and Reprogramming of the Immune Microenvironment
    Zhuang, Zhan
    Zhou, Jinglin
    Qiu, Minglian
    Li, Jiamian
    Lin, Zhuangheng
    Yi, Huihan
    Liu, Xuerong
    Huang, Changyu
    Tang, Binghua
    Liu, Bo
    Li, Xu
    CANCERS, 2024, 16 (04)
  • [27] Combination of an anti-angiogenic antibody with PD1/PDL1 blockade agents produces synergistic anti-tumor efficacy in preclinical models.
    Xue, Liting
    Zhang, Haoyu
    Wang, Qian
    Li, Feng
    Li, Xinxin
    Yu, Xiaohong
    Lu, Zhihong
    Huang, Yue
    Yang, Wenqing
    CANCER RESEARCH, 2021, 81 (13)
  • [28] Combination of CTLA-4 blockade with anti-CD40/IL-2 immunotherapy augments the CD8+T cell response in resting and tumor-bearing mice
    Sckisel, Gail
    Nzigira, Ngabo
    Hurwitz, Andrew
    Blazar, Bruce
    Murphy, William
    JOURNAL OF IMMUNOLOGY, 2010, 184
  • [29] Combination of EGFR antibody with PD-1 pathway inhibitors improves anti-tumor efficacy and enhances intra-tumor immune response in preclinical mouse tumor models
    Kandaswamy, Veena
    Forest, Amelie
    Deroose, Marianne
    Schaer, David A.
    Chen, Ting
    Liu, Shengwu
    Surguladze, David
    Yao, Yung-mae
    Doman, Thompson
    Hall, Gerald
    Wong, Kwok-Kin
    Kalos, Michael
    Novosiadly, Ruslan D.
    CANCER RESEARCH, 2018, 78 (13)
  • [30] CTLA-4 blockade in combination with xenogeneic DNA vaccines enhances T-cell responses, tumor immunity and autoimmunity to self antigens in animal and cellular model systems
    Gregor, PD
    Wolchok, JD
    Ferrone, CR
    Buchinshky, H
    Guevara-Patiño, JA
    Perales, MA
    Mortazavi, F
    Bacich, D
    Heston, W
    Latouche, JB
    Sadelain, M
    Allison, JP
    Scher, HI
    Houghton, AN
    VACCINE, 2004, 22 (13-14) : 1700 - 1708