An open-label clinical trial of RP2 and RP3 oncolytic immunotherapy in combination with atezolizumab and bevacizumab for the treatment of patients with advanced colorectal carcinoma

被引:0
|
作者
Shepard, Dale Randall
Ahmed, Muneeb
Bekaii-Saab, Tanios S.
Wolff, Johannes
机构
[1] Cleveland Clin, Cleveland, OH USA
[2] Beth Israel Deaconess Med Ctr, Boston, MA USA
[3] Mayo Clin, Phoenix, AZ USA
[4] Replimune Inc, Woburn, MA USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
TPS3628
引用
收藏
页数:1
相关论文
共 50 条
  • [21] Open-label phase I trial of vandetanib in combination with mFOLFOX6 in patients with advanced colorectal cancer
    Michael, Michael
    Gibbs, Peter
    Smith, Robert
    Godwood, Alex
    Oliver, Stuart
    Tebbutt, Niall
    INVESTIGATIONAL NEW DRUGS, 2009, 27 (03) : 253 - 261
  • [22] Open-label phase I trial of vandetanib in combination with mFOLFOX6 in patients with advanced colorectal cancer
    Michael Michael
    Peter Gibbs
    Robert Smith
    Alex Godwood
    Stuart Oliver
    Niall Tebbutt
    Investigational New Drugs, 2009, 27 : 253 - 261
  • [23] A randomized, controlled, open-label, phase II study of cemiplimab as a single agent and in combination with RP1 in patients with advanced cutaneous squamous cell carcinoma [CERPASS]
    Haydon, A. M.
    Alamgeer, M.
    Brungs, D.
    Collichio, F.
    Khushalani, N. I.
    Colevas, A. D.
    Rischin, D.
    Kudchadkar, R.
    Chai-Ho, W.
    Daniels, G.
    Lutzky, J.
    Lee, J. H.
    Bowyer, S.
    Migden, M. R.
    Sheladia, P.
    Bommareddy, P. K.
    He, S.
    Andreu-Vieyra, C.
    Fury, M. G.
    Hill, A.
    ANNALS OF ONCOLOGY, 2021, 32 : S904 - S904
  • [24] Camrelizumab in Combination with Apatinib in Patients with Advanced Hepatocellular Carcinoma (RESCUE): A for Nonrandomized, Open-label, Phase II Trial
    Xu, Jianming
    Shen, Jie
    Gu, Shanzhi
    Zhang, Yun
    Wu, Lihua
    Wu, Jian
    Shao, Guoliang
    Zhang, Yanqiao
    Xu, Li
    Yin, Tao
    Liu, Jingfeng
    Ren, Zhenggang
    Xiong, Jianping
    Mao, Xianhai
    Zhang, Ling
    Yang, Jiayin
    Li, Lequn
    Chen, Xiaoming
    Wang, Zhiming
    Gu, Kangsheng
    Chen, Xi
    Pan, Zhanyu
    Ma, Kuansheng
    Zhou, Xinmin
    Yu, Zujiang
    Li, Enxiao
    Yin, Guowen
    Zhang, Xiao
    Wang, Shuni
    Wang, Quanren
    CLINICAL CANCER RESEARCH, 2021, 27 (04) : 1003 - 1011
  • [25] BIODISTRIBUTION AND SHEDDING ANALYSIS FOLLOWING TREATMENT WITH RP1 ONCOLYTIC IMMUNOTHERAPY IN THE SKIN CANCER PATIENTS FROM THE IGNYTE CLINICAL TRIAL
    Milhem, Mohammed
    VanderWalde, Ari
    Bowles, Tawnya
    Sacco, Joseph
    Olsson-Brown, Anna
    Niu, Jiaxin
    Tsai, Katy
    Chesney, Jason
    Chmielowski, Bartosz
    Samson, Adel
    Rhodes, Terence
    In, Gino
    Pavlick, Anna
    Wise-Draper, Trisha
    Sanmamed, Miguel
    Kalbasi, Alireza
    Love, Colin
    Clack, Aaron
    Hou, Jeannie
    Bommareddy, Praveen
    Coffin, Robert
    Middleton, Mark
    Harrington, Kevin
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 : A643 - A643
  • [26] Clinical biomarker studies with two fusion-enhanced versions of oncolytic HSV (RP1 and RP2) alone and in combination with nivolumab in cancer patients indicate potent immune activation.
    Harrington, Kevin J.
    Aroldi, Francesca
    Sacco, Joseph J.
    Milhem, Mohammed M.
    Curti, Brendan D.
    Vanderwalde, Ari M.
    Baum, Scott
    Samson, Adel
    Pavlick, Anna C.
    Chesney, Jason A.
    Niu, Jiaxin
    Rhodes, Terence D.
    Bowles, Tawnya L.
    Conry, Robert
    Olsson-Brown, Anna
    Laux, Douglas E.
    Nenclares, Pablo
    Menezes, Lavita
    Deterding, Alex
    Roulstone, Victoria
    Kyula, Joan
    Thomas, Suzanne
    Bommareddy, Praveen K.
    Samakoglu, Selda
    Pirzkall, Andrea
    Coffin, Robert S.
    Middleton, Mark R.
    CANCER RESEARCH, 2021, 81 (13)
  • [27] Initial results from an open-label phase 1b/2 study of RP1 oncolytic immunotherapy in solid organ transplant recipients with advanced cutaneous malignancies (ARTACUS)
    Migden, Michael R.
    Chai-Ho, Wanxing
    Daniels, Gregory A.
    Medina, Theresa
    Wise-Draper, Trisha M.
    Kheterpal, Meenal
    Tang, Jennifer C.
    Ibrahim, Sherrif F.
    Bolotin, Diana
    Verschraegen, Claire
    Zeitouni, Nathalie C.
    Tsai, Katy K.
    Donthireddy, Laxminarasimha
    Bommareddy, Praveen K.
    Hou, Jeannie W.
    Hong, Walter
    Davar, Diwakar
    CANCER RESEARCH, 2024, 84 (07)
  • [28] Sequential versus combination chemotherapy for the treatment of advanced colorectal cancer (FFCD 2000-05): an open-label, randomised, phase 3 trial
    Ducreux, Michel
    Malka, David
    Mendiboure, Jean
    Etienne, Pierre-Luc
    Texereau, Patrick
    Auby, Dominique
    Rougier, Philippe
    Gasmi, Mohamed
    Castaing, Marine
    Abbas, Moncef
    Michel, Pierre
    Gargot, Dany
    Azzedine, Ahmed
    Lombard-Bohas, Catherine
    Geoffroy, Patrick
    Denis, Bernard
    Pignon, Jean-Pierre
    Bedenne, Laurent
    Bouche, Olivier
    LANCET ONCOLOGY, 2011, 12 (11): : 1032 - 1044
  • [29] AN OPEN-LABEL, MULTICENTER, PHASE 1/2 CLINICAL TRIAL OF RP1, AN ENHANCED POTENCY ONCOLYTIC HSV, COMBINED WITH NIVOLUMAB: UPDATED RESULTS FROM THE SKIN CANCER COHORTS
    Middleton, Mark
    Aroldi, Francesca
    Sacco, Joseph
    Milhem, Mohammed
    Curti, Brendan
    VanderWalde, Ari
    Baum, Scott
    Samson, Adel
    Pavlick, Anna
    Chesney, Jason
    Niu, Jiaxin
    Rhodes, Terence
    Bowles, Tawnya
    Conry, Robert
    Olsson-Brown, Anna
    Laux, Douglas Earl
    Kaufman, Howard
    Bommareddy, Praveen
    Deterding, Alex
    Samakoglu, Selda
    Coffin, Robert
    Harrington, Kevin
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 : A257 - A257
  • [30] Safety, efficacy, and biomarker results from an open-label, multicenter, phase 1 study of RP2 alone or combined with nivolumab in a cohort of patients with uveal melanoma
    Sacco, Joseph J.
    Harrington, Kevin Joseph
    Olsson-Brown, Anna
    Chan, Tze Y.
    Nenclares, Pablo
    Leslie, Isla
    Bommareddy, Praveen
    Kalbasi, Alireza
    Xie, Ben
    Mishal, Moran
    Cohan, David Michael
    Skolariki, Aglaia
    Middleton, Mark R.
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)