A Novel Idea of Sulfamic Acid as an Efficient Catalyst for the Synthesis of 2-Azapyrrolizidine Derivatives

被引：0

作者：

Tafer, Radia ^{[1
]}

Boulcina, Raouf ^{[1
]}

Debache, Abdelmadjid ^{[1
]}

机构：

[1] Mentouri Constantine Univ, Lab Synth Mol Biol Interest, Constantine 25000, Algeria

来源：

CURRENT ORGANOCATALYSIS | 2023年 / 10卷 / 01期

关键词：

Multicomponent reactions; one-pot synthesis; homogeneous catalysis; hydantoin; 2-azapyrrolizidines; sulfamic acid; ONE-POT SYNTHESIS; MULTICOMPONENT REACTIONS; DIASTEREOSELECTIVE SYNTHESIS; PYRROLIZIDINE ALKALOIDS; REGIOSPECIFIC DOMINO; MEDICINAL-PLANTS; HYDANTOIN; CARBODIIMIDES; INHIBITOR;

D O I：

10.2174/2213337209666220728114131

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Background The synthesis of 2-azapyrrolizidine scaffolds has fascinated scientists due to their potential biological activities. Objective An efficient and environmentally sustainable synthetic method has been presented to synthesize structurally various 2-azapyrrolizidines via a three-component reaction. Methods The condensation of aldehydes, hydantoin, and malononitrile in the presence of green and sustainable sulfamic acid as catalyst in mild conditions has been achieved. Results The present protocol leads, in most cases, to the desired products in high yields. Conclusion The synthetic efficiency and operational simplicity make the present procedure cost effective, time efficient and eco-friendly for the synthesis of substituted 2-azapyrrolizidines.

引用

页码：19 / 25

页数：7

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