Assessment of Brainstem Functional Organization in Healthy Adults and Overactive Bladder Patients Using Ultra-High Field fMRI

被引:4
|
作者
Chadily, Susana Fernandez [1 ]
de Rijk, Mathijs M. M. [1 ,2 ]
Janssen, Janine M. W. [2 ]
van den Hurk, Job [1 ,3 ]
van Koeveringe, Gommert A. A. [1 ,2 ]
机构
[1] Maastricht Univ, Fac Hlth Med & Life Sci, Sch Mental Hlth & Neurosci, Dept Urol, NL-6229 ER Maastricht, Netherlands
[2] Maastricht Univ Med Ctr MUMC, Dept Urol, NL-6229 HX Maastricht, Netherlands
[3] Scannexus Ultra High Field MRI Ctr, NL-6229 EV Maastricht, Netherlands
关键词
overactive bladder syndrome; neuro-urology; fMRI; PAG; NEURAL-CONTROL; INCONTINENCE; URGENCY; WOMEN;
D O I
10.3390/biomedicines11020403
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The pathophysiological mechanisms of overactive bladder syndrome (OAB) remain largely unknown, with major involvement of the central nervous system (CNS). The periaqueductal gray (PAG) is a brainstem area which is indicated to play an essential role in bidirectional communication between the bladder and the CNS. We aimed to assess consistency of PAG functional organization across different bladder sensory states in OAB patients. We propose, that PAG functional organization patterns across sensory states will differ between controls and OAB patients. We analyzed fMRI scans at 7 Tesla from six controls and two OAB patients. The Louvain module detection algorithm was applied to parcellate the PAG in empty and full bladder states. We assessed within-subject consistency and investigated differences in this consistency between both groups. High within-subject agreement of PAG parcellations between empty and full bladder states was demonstrated in both groups. Additionally, we showed that the correlations between PAG clusters in both bladder states were significantly different in patients compared to controls (p = 0.039). The methods introduced here offer a promising tool to assess functional organization of the PAG and understand the underlying pathology and the role of this region in OAB syndrome.
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页数:9
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