Prediction of the next major outbreak of COVID-19 in Mainland China and a vaccination strategy for it

被引:3
|
作者
Wu, Yuanyuan [1 ]
Zhou, Weike [2 ]
Tang, Sanyi [1 ]
Cheke, Robert A. [3 ,4 ]
Wang, Xia [1 ]
机构
[1] Shaanxi Normal Univ, Sch Math & Stat, Xian 710119, Peoples R China
[2] Northwest Univ, Sch Math, Xian 710127, Peoples R China
[3] Univ Greenwich Medway, Nat Resources Inst, Cent Ave, Chatham ME4 4TB, Kent, England
[4] Imperial Coll London, Dept Infect Dis Epidemiol, Sch Publ Hlth, St Marys Campus,Norfolk Pl, London W2 1PG, England
来源
ROYAL SOCIETY OPEN SCIENCE | 2023年 / 10卷 / 08期
关键词
COVID-19; age-structured model; vaccination strategy; immunity waning; GLOBAL STABILITY; EPIDEMIC MODEL; AGE; DYNAMICS;
D O I
10.1098/rsos.230655
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
After the widespread prevalence of COVID-19 at the end of 2022 in Mainland China, a major concern is when will the second major outbreak occur and with what prevalence and fatality rates will it be associated with, as peoples' immunity from natural infection subsides. To address this, we established an age-structured model considering vaccine and infection-derived immunity, fitted an immunity-waning curve, and calibrated the model using the epidemic and vaccination data from Hong Kong in 2022. The model and the situation of the first major epidemic in Mainland China were then used to predict the prevalence rate, fatality rate and peak time of the second wave. In addition, the controlling effects of different vaccination strategies on the second major outbreak are discussed. Finally, a characterization indicator for the level of population immunity was provided. We conclude that if the prevalence of the first major epidemic was 80%, the prevalence rate of the second major outbreak would be about 37.64%, and the peak time would have been July 2 2023. Strengthening vaccination can effectively delay the peak of the second wave of the epidemic and reduce the prevalence.
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页数:14
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