Prostaglandin E2 Production by Brain Endothelial Cells and the Generation of Fever

被引：4
|
作者：
Blomqvist, Anders [1 ]
机构：
[1] Linkoping Univ, Fac Med & Hlth Sci, Dept Biomed & Clin Sci, Div Neurobiol, Linkoping, Sweden
来源：
DNA AND CELL BIOLOGY | 2023年 / 42卷 / 03期
基金：
瑞典研究理事会;
关键词：
cyclooxygenase-2; microsomal prostaglandin E synthase-1; lipopolysaccharide; mice; intravenous; Slco1c1; promoter; LIPOPOLYSACCHARIDE-INDUCED FEVER; CYCLOOXYGENASE-2; MESSENGER-RNA; PITUITARY-ADRENAL AXIS; IMMUNE-INDUCED FEVER; RAT-BRAIN; LOCALIZED INFLAMMATION; SYSTEMIC INFLAMMATION; SYNTHESIZING ENZYMES; E SYNTHASE-1; GUINEA-PIGS;
D O I：
10.1089/dna.2022.0662
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We recently demonstrated that prostaglandin production in brain endothelial cells is both necessary and sufficient for the generation of fever during systemic immune challenge. I here discuss this finding in light of the previous literature and point to some unresolved issues.
引用
收藏
页码：107 / 112
页数：6
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