Article Serum proteome profiling reveals heparanase as a candidate biomarker for chronic thromboembolic pulmonary hypertension

被引：5
|
作者：
Zhang, Yunxia [1 ,2 ,3 ,4 ,5 ]
Zhang, Meng [6 ]
Yang, Hongwei [1 ,2 ,3 ,4 ,5 ,7 ]
Li, Haobo [1 ,2 ,3 ,4 ,5 ,8 ]
Ma, Shuangshuang [1 ,2 ,3 ,4 ,5 ,9 ]
Xi, Linfeng [1 ,2 ,3 ,4 ,5 ,10 ]
Li, Yishan [1 ,2 ,3 ,4 ,5 ,11 ]
Li, Xincheng [1 ,2 ,3 ,4 ,5 ,12 ]
Fu, Zhihui [1 ,2 ,3 ,4 ,5 ,8 ]
Zhang, Zhu [1 ,2 ,3 ,4 ,5 ]
Zhang, Shuai [1 ,2 ,3 ,4 ,5 ]
Gao, Qian [1 ,2 ,3 ,4 ,5 ]
Huang, Qiang [1 ,2 ,3 ,4 ,5 ]
Wan, Jun
Xie, Wanmu [1 ,2 ,3 ,4 ,5 ]
Li, Jifeng [13 ,14 ,15 ,16 ]
Yang, Peiran [1 ,2 ,3 ,4 ,5 ,17 ,18 ]
Zhai, Zhenguo [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Natl Ctr Resp Med, Beijing, Peoples R China
[2] State Key Lab Resp Hlth & Multimorbid, Beijing, Peoples R China
[3] Natl Clin Res Ctr Resp Dis, Beijing, Peoples R China
[4] Chinese Acad Med Sci, Inst Resp Med, Beijing, Peoples R China
[5] China Japan Friendship Hosp, Ctr Resp Med, Dept Pulm & Crit Care Med, Beijing, Peoples R China
[6] Capital Med Univ, Beijing Anzhen Hosp, Dept Pulm & Crit Care Med, Beijing, Peoples R China
[7] Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Chongqing, Peoples R China
[8] Chinese Acad Med Sci & Peking Union Med Coll, China Japan Friendship Hosp, Beijing, Peoples R China
[9] Beijing Univ Chinese Med, Beijing, Peoples R China
[10] Capital Med Univ, China Japan Friendship Hosp, Beijing, Peoples R China
[11] Shanxi Med Univ, Clin Med Coll 1, Taiyuan, Peoples R China
[12] Harbin Med Univ, Harbin, Peoples R China
[13] Capital Med Univ, Beijing Chao Yang Hosp, Dept Resp & Crit Care Med, Beijing, Peoples R China
[14] Capital Med Univ, Beijing Chao Yang Hosp, Beijing Key Lab Resp & Pulm Circulat Disorders, Beijing, Peoples R China
[15] Capital Med Univ, Beijing Chao Yang Hosp, Beijing Inst Resp Med, Beijing, Peoples R China
[16] Capital Med Univ, Dept Resp Dis, Beijing, Peoples R China
[17] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Physiol, State Key Lab Resp Hlth & Multimorbid, Beijing, Peoples R China
[18] Peking Union Med Coll, Sch Basic Med, Beijing, Peoples R China
来源：
ISCIENCE | 2024年 / 27卷 / 02期
关键词：
ARTERIAL-HYPERTENSION; HEPARIN;
D O I：
10.1016/j.isci.2024.108930
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Determining novel biomarkers for early identification of chronic thromboembolic pulmonary hypertension (CTEPH) could improve patient outcomes. We used the isobaric tag for relative and absolute quantitation approach to compare the serum protein profiles between CTEPH patients and the controls. Bioinformatics analyses and ELISA were also performed. We identified three proteins including heparanase (HPSE), gelsolin (GSN), and secreted protein acidic and rich in cysteine (SPARC) had significant changes in CTEPH. The receiver operating characteristic curve analysis showed that the areas under the curve of HPSE in CTEPH diagnosis were 0.988. Furthermore, HPSE was correlated with multiple parameters of right ventricular function. HPSE concentrations were significantly higher in patients with a low TAPSE/sPAP ratio (%0.31 mm/mmHg) (65.4 [60.5,68.0] vs. 59.9 [35.9,63.2] ng/mL, p < 0.05). The CTEPH patients treated by balloon pulmonary angioplasty had significantly lower HPSE levels. The study demonstrates that HPSE may be a promising biomarker for noninvasive detection of CTEPH.
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页数：14
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