Regulatory T cells in allergic inflammation

被引：7
|
作者：
Benamar, Mehdi [1 ,2 ]
Chen, Qian [1 ,2 ]
Martinez-Blanco, Monica [1 ,2 ]
Chatila, Talal A. [1 ,2 ]
机构：
[1] Boston Childrens Hosp, Div Immunol, Boston, MA 02115 USA
[2] Harvard Med Sch, Dept Pediat, Boston, MA USA
来源：
SEMINARS IN IMMUNOLOGY | 2023年 / 70卷
基金：
美国国家卫生研究院;
关键词：
SYNCYTIAL VIRUS-INFECTION; TUFT CELLS; ATOPIC-DERMATITIS; TYPE-2; IMMUNITY; IMMUNOLOGICAL-TOLERANCE; PULMONARY EOSINOPHILIA; AIRWAY INFLAMMATION; FOOD ALLERGY; ASTHMA; PROMOTES;
D O I：
10.1016/j.smim.2023.101847
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Regulatory T (Treg) cells maintain immune tolerance to allergens at the environmental interfaces in the airways, skin and gut, marshalling in the process distinct immune regulatory circuits operative in the respective tissues. Treg cells are coordinately mobilized with allergic effector mechanisms in the context of a tissue protective allergic inflammatory response against parasites, toxins and potentially harmful allergens, serving to both limit the inflammation and promote local tissue repair. Allergic diseases are associated with subverted Treg cell responses whereby a chronic allergic inflammatory environment can skew Treg cells toward pathogenic phenotypes that both perpetuate and aggravate disease. Interruption of Treg cell subversion in chronic allergic inflammatory conditions may thus provide novel therapeutic strategies by re-establishing effective immune regulation.
引用
收藏
页数：8
相关论文
共 50 条
  • [21] The absence of CD8+cells affects T regulatory cells and activated T helper cells in a mouse model of allergic inflammation
    Malmhall, C.
    Lu, Y.
    Lotvall, J.
    Bossios, A.
    ALLERGY, 2009, 64 : 138 - 139
  • [22] Regulatory T cells, allergic diseases, and cancer
    Mascitelli, Luca
    Pezzetta, Francesca
    CHEST, 2008, 133 (03) : 832 - 832
  • [23] T regulatory cells and the control of allergic disease
    Xystrakis, E
    Boswell, SE
    Hawrylowicz, C
    EXPERT OPINION ON BIOLOGICAL THERAPY, 2006, 6 (02) : 121 - 133
  • [24] Regulatory T cells and their role in allergic disease
    Conrad, Melanie L.
    Barrientos, Gabriela
    Cai, Xuejun
    Mukherjee, Saikat
    Das, Mrinmoy
    Stephen-Victor, Emmanuel
    Harb, Hani
    ALLERGY, 2025, 80 (01) : 77 - 93
  • [25] Inhibition of the allergic response by regulatory T cells
    Stock, P
    DeKruyff, RH
    Umetsu, DT
    CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 6 (01) : 12 - 16
  • [26] Requirement for γδ T cells in allergic airway inflammation
    Zuany-Amorim, C
    Ruffié, C
    Hailé, S
    Vargaftig, BB
    Pereira, P
    Pretolani, M
    SCIENCE, 1998, 280 (5367) : 1265 - 1267
  • [27] Deficiency of regulatory B cells increases allergic airway inflammation
    S. K. Lundy
    A. A. Berlin
    T. F. Martens
    N. W. Lukacs
    Inflammation Research, 2005, 54 : 514 - 521
  • [28] Deficiency of regulatory B cells increases allergic airway inflammation
    Lundy, SK
    Berlin, AA
    Martens, TF
    Lukacs, NW
    INFLAMMATION RESEARCH, 2005, 54 (12) : 514 - 521
  • [29] Myeloid-Derived Regulatory Cells in Allergic Airway Inflammation
    Deshane, J. S.
    Zmijewski, J. W.
    Spell, M.
    Lai, J.
    Abraham, E.
    Chaplin, D. D.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 123 (02) : S54 - S54
  • [30] Serine proteases inhibitor reduce allergic inflammation by regulatory T cells in a house dust mite allergic rhinitis mouse model
    Kim, S. W.
    Kim, B-Y
    Shin, J-H
    Park, H. R.
    Kim, S. W.
    ALLERGY, 2013, 68 : 355 - 356
12345